지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제15권 제3호
- 발행연도
- 2016.1
- 수록면
- 75 - 81 (7page)
이용수
초록· 키워드
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Background and Purpose During Vietnam War, many Korean soldiers were dispatched to fight in the war where they were exposed toAgent Orange. Until now, there exist only limited evidence on existence of association between exposure to Agent Orange and Parkinson’sdisease (PD). To elucidate the effects of Agent Orange exposure on PD, we compared the clinical characteristics and radiolabeled 18F-FP-CITPET uptake between patients with Agent Orange exposure and patients with Agent Orange no-exposure.
Methods We retrospectively evaluated 143 patients exposed to Agent Orange and 500 patients with no exposure to Agent Orange from ourmovement clinics database. The differences between clinical characteristics and pattern of 18F-FP-CIT PET uptake were investigated.
Results Among Unified Parkinson’s Disease Rating Scale III motor subscales, tremor at rest, rigidity, finger taps, and rapid alternatingmovement was significantly higher in patients exposed to Agent Orange as compared to patients with no exposure to Agent Orange. The facialexpression score was significantly lower in patients exposed to Agent Orange as compared to patients with no exposure to Agent Orange.
Compared to patients not exposed to Agent Orange, all basal ganglia areas (contra- and ipsilateral caudate nucleus, anterior putamen, andposterior putamen) showed a lower18F-FP-CIT uptake and higher asymmetry index of anterior and posterior putamen was found in patientsexposed to Agent Orange. The caudate/putamen ratio was significantly lower in patients exposed to Agent Orange as compared to patientswith no exposure to Agent Orange.
Conclusions This study showed a different clinical profile and FP-CIT PET findings between patients exposed to Agent Orange as comparedto patients with no exposure to Agent Orange. This finding suggests the possibility of different pathophysiology of PD in patients exposedto Agent Orange from idiopathic PD.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Hughes AJ / 1992 / Accuracy of clinical diagnosis of idiopathic Parkinson’s disease : a clinico-pathological study of 100 cases / J Neurol Neurosurg Psychiatry 55:181~184
Decouflé P / 1992 / Self-reported health status of Vietnam veterans in relation to perceived exposure to herbicides and combat / Am J Epidemiol 135:312~323
Lewis SJ / 2005 / Heterogeneity of Parkinson’s disease in the early clinical stages using a data driven approach / J Neurol Neurosurg Psychiatry 76:343~348
Isaias IU / 2007 / [123I]FP-CIT striatal binding in early Parkinson’s disease patients with tremor vs. akinetic-rigid onset / Neuroreport 18:1499~1502
Zober A / 1994 / Morbidity follow up study of BASF employees exposed to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin(TCDD)after a 1953 chemical reactor incident / Occup Environ Med 51:479~486
Decouflé P / 1992 / Self-reported health status of Vietnam veterans in relation to perceived exposure to herbicides and combat / Am J Epidemiol 135:312~323
Lewis SJ / 2005 / Heterogeneity of Parkinson’s disease in the early clinical stages using a data driven approach / J Neurol Neurosurg Psychiatry 76:343~348
Isaias IU / 2007 / [123I]FP-CIT striatal binding in early Parkinson’s disease patients with tremor vs. akinetic-rigid onset / Neuroreport 18:1499~1502
Zober A / 1994 / Morbidity follow up study of BASF employees exposed to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin(TCDD)after a 1953 chemical reactor incident / Occup Environ Med 51:479~486
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