지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 13 - 19 (7page)
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초록· 키워드
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Objectives: The present study investigated the protective effect of Wattakaka (W.) volubilis leaf extract against streptozotocin (STZ)-induced diabetes in rats.
Methods: Male Wistar rats were divided into five groups (with six rats in each group) and were fed ad libitum. The rats were fasted for sixteen hours before diabetes was induced by injecting a single dose of 90 mg/kg body weight of STZ in 0.9-percent normal saline through an intraperitoneal route. The five groups were as follows: Group 1: normal control (saline-treated), Group 2: untreated diabetic rats, Groups 3 and 4: diabetic rats treated orally with petroleum ether cold maceration extract (PEME) of W. volubilis (50 and 100 mg/kg body weight), and Group 5: diabetic rats treated orally with metformin (250 mg/kg body weight). All rats received treatment for 21 days. For the STZ-induced diabetic rats, the blood-glucose, α-amylase, total protein and alanine transaminase (ALT) levels were measured on days 7, 14 and 21 of the treatment with PEME of W. volubilis and the treatment with metformin. Histopathological changes in the liver were examined with hematoxylin-eosin staining. Morphological changes in the liver were also examined with glutaraldehyde fixation.
Results: The treatments with PEME of W. volubilis and with metformin in experimental rats by oral injections for 21 days produced reductions in the levels of serum biochemical markers. Histopathology and scanning electron microscopy results showed that the administrations of PEME of W. volubilis and of metformin suppressed the generation of abnormal liver cells in the STZ-treated rats.
Conclusion: These results suggest that both PEME of W. volubilis and metformin have a protective effect against STZ-induced diabetes.
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참고문헌 (18)
참고문헌 신청
Agbaje EO. / 2009 / Biochemical and toxicological studies of aqueous extract of syzigium aromaticum(L. )merr. & perry(myrtaceae)in rodent / Aft J Tradit Complement Alter
Almdal JP. / 1988 / Strict insulin therapy normalizes organ nitrogen contents and capacity of urea nitrogen synthesis in experimental diabetes in rats / Diabetolgia 31 (2) :
Andallu B. / 2002 / Control of hyperglycemic and retardation of cataract by mulberry(Morusindica. L)leaves in streptozotocin diabetic rats / Ind J Exp Biol 40 (7) : 791 ~ 795
Ayyanar M. / 2008 / Traditional herbal medicines used for the treatment of diabetes among two major tribal groups in South Tamil, Nadu, India / Ethnobotanical Leaflets 12 :
Davern TJ / 2002 / Sleisenger and Fordtran’s Gastrointestinal and liver disease: pathophysiology, diagnosis, management. 7th ed / W B Saunders Co : 1227 ~ 1228
Almdal JP. / 1988 / Strict insulin therapy normalizes organ nitrogen contents and capacity of urea nitrogen synthesis in experimental diabetes in rats / Diabetolgia 31 (2) :
Andallu B. / 2002 / Control of hyperglycemic and retardation of cataract by mulberry(Morusindica. L)leaves in streptozotocin diabetic rats / Ind J Exp Biol 40 (7) : 791 ~ 795
Ayyanar M. / 2008 / Traditional herbal medicines used for the treatment of diabetes among two major tribal groups in South Tamil, Nadu, India / Ethnobotanical Leaflets 12 :
Davern TJ / 2002 / Sleisenger and Fordtran’s Gastrointestinal and liver disease: pathophysiology, diagnosis, management. 7th ed / W B Saunders Co : 1227 ~ 1228
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