지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 7 - 15 (9page)
이용수
초록· 키워드
오류제보하기
Objectives: The present study investigated the toxic properties of petroleum ether extract of Wattakaka (W.) volubilis in Wistar female rats.
Methods: An in vitro brine shrimp lethality bioassay was studied in A. Salina nauplii, and the lethality concentrations were assessed for petroleum ether extract of W. volubilis. A water soluble portion of the test extract was used in different concentrations from 100-1000 μg/mL of 1 mg/mL stock solution. A 24-hours incubation with a 1-mL aliquot in 50 mL of aerated sea water was considered to calculate the percentage rate of dead nauplii with test extract administration against a potassium-dichromate positive control. The acute and the sub-acute toxicities of petroleum ether extract of W. volubilis were evaluated orally by using gavage in female Wistar rats. Food and water intake, body weight, general behavioral changes and mortality of animals were noted. Toxicity or death was evaluated following the administration of petroleum ether extract for 28 consecutive days in the female rats. Serum biochemical parameters, such as alanine aminotransferase (ALT), alkaline phosphatase (ALP), bilirubin, total cholesterol, triglyceride, total protein, glucose, urea, creatinine, sodium, potassium and α-amylase levels, were measured in the toxicity evaluations. Pathological changes in isolated organs, such as the liver, kidneys, and pancreas, were also examined using hematoxylin and eosin dye fixation after the end of the test extract’s administration.
Results: The results of the brine-shrimp assay indicate that the evaluated concentrations of petroleum ether extract of W. volubilis were found to be non-toxic. In the acute and the sub-acute toxicity evaluations, no significant differences were observed between the control animals and the animals treated with extract of W. volubilis. No abnormal histological changes were observed in any of the animal groups treated with petroleum ether extract of W. volubilis.
Conclusion: These results suggest that petroleum ether extract of W. volubilis has a non-toxic effect in Wistar female rats.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Mauer SM. / 1981 / The kidney in diabetes / Am J Med 70(3):603~612
Almadal TP. / 1988 / Strict insulin treatment normalizes the organic nitrogen contents and the capacity of urea–N synthesis in experimental diabetes in rats / Diabetologica 31(2):114~118
Kerl ME. / 2001 / Diabetic ketoacidosis : pathophysiology and clinical laboratory presentation / Comp Cont Educ Pract Vet 23(3):220~229
Tarling CA. / 2008 / The search for novel human pancreatic alpha-amylase inhibitors : high-throughput screening of terrestrial and marine natural product extracts / Chem Bio Chem 9(3):433~438
Arts JH. / 2004 / Subacute(28-day)toxicity of furfural in fischer 344 rats : a comparison of the oral and inhalation route / Food Chem Toxicol 42 (9) : 1389 ~ 1399
Almadal TP. / 1988 / Strict insulin treatment normalizes the organic nitrogen contents and the capacity of urea–N synthesis in experimental diabetes in rats / Diabetologica 31(2):114~118
Kerl ME. / 2001 / Diabetic ketoacidosis : pathophysiology and clinical laboratory presentation / Comp Cont Educ Pract Vet 23(3):220~229
Tarling CA. / 2008 / The search for novel human pancreatic alpha-amylase inhibitors : high-throughput screening of terrestrial and marine natural product extracts / Chem Bio Chem 9(3):433~438
Arts JH. / 2004 / Subacute(28-day)toxicity of furfural in fischer 344 rats : a comparison of the oral and inhalation route / Food Chem Toxicol 42 (9) : 1389 ~ 1399
이 논문의 저자 정보
최근 본 자료
댓글(0)
0