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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제14권 제4호
- 발행연도
- 2015.1
- 수록면
- 172 - 175 (4page)
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초록· 키워드
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Background Creutzfeldt-Jakob disease (CJD) shares common clinical features with Hashimoto’s encephalopathy (HE). The 14-3-3 proteinis a relatively sensitive and specific marker of CJD but is not commonly detected in HE. We report the case of a patient with HE with unusualfeatures including positive 14-3-3 protein in the cerebrospinal fluid (CSF) and an atypical course mimicking that of CJD.
Case Report A 64-year-old male was admitted due to acute-onset cognitive dysfunction. HE was suspected based on increased titers ofanti-thyroid microsomal antibody and an excellent response to steroid. However, 14-3-3 protein was detected in the CSF and a recurrent attackwith progressive cognitive decline, pyramidal symptoms and myoclonus mimicking CJD occurred. Cognitive dysfunction showed progressiveworsening and the response to steroid treatment was decreased.
Conclusions 14-3-3 protein could be considered a general marker of neuronal destruction and not specific to CJD. The clinical manifestationsof HE are variable and its diagnosis is difficult due to the lack of a specific phenotype and reliable diagnostic criteria. We recommendthat patients with clinical features of CJD and antithyroid antibodies should be considered for empirical steroid treatment for HE, despite apositive result for 14-3-3 protein.
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참고문헌 (9)
참고문헌 신청
Chong JY / 2003 / Hashimoto encephalopathy: syndrome or myth? / Arch Neurol 60 : 164 ~ 171
Doherty CP / 2002 / Hashimoto’s encephalopathy mimicking Creutzfeldt-Jakob disease: brain biopsy findings / J Neurol Neurosurg Psychiatry 73 : 601 ~ 602
Hernandez Echebarria LE / 2000 / Detection of 14-3-3 protein in the CSF of a patient with Hashimoto’s encephalopathy / Neurology 54 : 1539 ~ 1540
Schroter A / 2000 / Magnetic resonance imaging in the clinical diagnosis of Creutzfeldt-Jakob disease / Arch Neurol 57 : 1751 ~ 1757
Seipelt M / 1999 / Hashimoto’s encephalitis as a differential diagnosis of Creutzfeldt-Jakob disease / J Neurol Neurosurg Psychiatry 66 : 172 ~ 176
Doherty CP / 2002 / Hashimoto’s encephalopathy mimicking Creutzfeldt-Jakob disease: brain biopsy findings / J Neurol Neurosurg Psychiatry 73 : 601 ~ 602
Hernandez Echebarria LE / 2000 / Detection of 14-3-3 protein in the CSF of a patient with Hashimoto’s encephalopathy / Neurology 54 : 1539 ~ 1540
Schroter A / 2000 / Magnetic resonance imaging in the clinical diagnosis of Creutzfeldt-Jakob disease / Arch Neurol 57 : 1751 ~ 1757
Seipelt M / 1999 / Hashimoto’s encephalitis as a differential diagnosis of Creutzfeldt-Jakob disease / J Neurol Neurosurg Psychiatry 66 : 172 ~ 176
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