지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제12권 제1호
- 발행연도
- 2013.1
- 수록면
- 29 - 32 (4page)
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Diffuse or focal white matter hyperintensity lesions on MRI have been reported in only a few patients with Hashimoto’s encephalopathy (HE), and anti-TPO antibody level is high in most cases. We report a 59-year-old woman who presented with acute onset of disorientation with confusion. Anti-thyroglobulin antibody was detected in high titer, although anti-TPO antibody titer was not high. Thyroid sonography and biopsy revealed Hashimoto’s thyroiditis. Initial fluid-attenuated inversion recovery (FLAIR) image and diffusion-weighted imaging (DWI) revealed ill-defined, diffuse, high-signal intensity lesions on the deep white matters and globus pallidus. Brain SPECT showed significant hypoperfusion in both basal ganglia (especially globus pallidus), frontal and temporal lobes. With the impression of HE, the patient was treated on a high-dose steroid. Over the next 15 weeks, her cognition improved to a nearly normal state and the MRI findings on DWI and FLAIR showed resolution paralleling her clinical improvement. Our case illustrates the peculiar changes in the MR findings, especially in DWI, with hypoperfusion on brain SPECT in patients with HE and allows for a greater understanding of the pathophysiology of HE.
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참고문헌 (9)
참고문헌 신청
Blanchin S / 2007 / Anti-thyroperoxidase antibodies from patients with Hashimoto’s encephalopathy bind to cerebellar astrocytes / J Neuroimmunol 192 : 13 ~ 20
Chang T / 2010 / Hashimoto encephalopathy: clinical and MRI improvement following high-dose corticosteroid therapy / Neurologist 16 : 394 ~ 396
Chen C / 2011 / Time course of Hashimoto’s encephalopathy revealed by MRI: Report of two cases / J Neurol Sci 300 : 169 ~ 172
Ferracci F / 2003 / Anti-thyroid antibodies in the CSF: their role in the pathogenesis of Hashimoto’s encephalopathy / Neurology 60 : 712 ~ 714
Forchetti CM / 1997 / Autoimmune thyroiditis and a rapidly progressive dementia: global hypoperfusion on SPECT scanning suggests a possible mechanism / Neurology 49 : 623 ~ 6
Chang T / 2010 / Hashimoto encephalopathy: clinical and MRI improvement following high-dose corticosteroid therapy / Neurologist 16 : 394 ~ 396
Chen C / 2011 / Time course of Hashimoto’s encephalopathy revealed by MRI: Report of two cases / J Neurol Sci 300 : 169 ~ 172
Ferracci F / 2003 / Anti-thyroid antibodies in the CSF: their role in the pathogenesis of Hashimoto’s encephalopathy / Neurology 60 : 712 ~ 714
Forchetti CM / 1997 / Autoimmune thyroiditis and a rapidly progressive dementia: global hypoperfusion on SPECT scanning suggests a possible mechanism / Neurology 49 : 623 ~ 6
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