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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제11권 제3호
- 발행연도
- 2012.1
- 수록면
- 104 - 110 (7page)
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Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor and nonmotor symptoms such as cognitive impairment and neuropsychiatric symptoms. The aim of this study was to investigate the spectrum of neuropsychiatric symptoms in PD according to cognitive function. Methods: One hundred twenty seven patients with PD were consecutively recruited. They had undergone an intensive interview with a neurologist and the Seoul Neuropsychological Screening Battery-dementia version, and were divided into three groups: 27 patients in PD with normal cognition (PDNC), 57 in PD with mild cognitive impairment (PDMCI), and 43 in PD with Dementia (PDD). Forty five healthy controls without memory complaints were also recruited. The caregivers of all participants administered the Caregiver-Administered Neuropsychiatric Inventory (CGA-NPI). Results: There were significant differences in the CGA-NPI score (22.8±20.9 vs. 6.4±10.1 vs. 1.7±3.9 vs. 1.0±1.6, p<0.001), and the prevalence of neuropsychiatric symptoms (100% vs. 64.9% vs. 37.0% vs. 44.4%, p<0.001) among PDD, PDMCI, PDNC and control groups. Depression was the most common symptom (43.3%), followed by anxiety (31.5%), apathy (26.8%), and night-time behavior (26.8%) in all PD patients. Delusion, hallucination, and aberrant motor behavior were observed frequently in PDD, but were rare in PDMCI. Conclusions: Depression was the most common neuropsychiatric symptom in PD. The presence of delusion, hallucination, or aberrant motor behavior may suggest PDD. The neuropsychiatric symptoms were not prevalent in PD with normal cognition.
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참고문헌 (22)
참고문헌 신청
Aarsland D / 2003 / Preva-lence and characteristics of dementia in parkinson disease: an 8-year prospective study / Arch Neurol 60 : 387 ~ 392
Aarsland D / 2007 / Neuropsychiatric symptoms in patients with Parkinson’s disease and dementia: frequency, profile and associated care giver stress / J Neurol Neurosurg Psy
Aarsland D / 2009 / The spectrum of neuropsychiatric symptoms in patients with early untreated Parkinson’s disease / J Neurol Neurosurg Psychiatry 80 : 928 ~ 930
Aarsland D / 2010 / Mild cognitive impairment in Parkinson disease: a multicenter pooled analysis / Neurology 75 : 1062 ~ 1069
Aarsland D / 2011 / Depression in Parkinson disease--epidemiology, mechanisms and management / Nat Rev Neurol 8 : 35 ~ 47
Aarsland D / 2007 / Neuropsychiatric symptoms in patients with Parkinson’s disease and dementia: frequency, profile and associated care giver stress / J Neurol Neurosurg Psy
Aarsland D / 2009 / The spectrum of neuropsychiatric symptoms in patients with early untreated Parkinson’s disease / J Neurol Neurosurg Psychiatry 80 : 928 ~ 930
Aarsland D / 2010 / Mild cognitive impairment in Parkinson disease: a multicenter pooled analysis / Neurology 75 : 1062 ~ 1069
Aarsland D / 2011 / Depression in Parkinson disease--epidemiology, mechanisms and management / Nat Rev Neurol 8 : 35 ~ 47
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