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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제11권 제2호
- 발행연도
- 2012.1
- 수록면
- 67 - 73 (7page)
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Background: Cerebral white matter lesions (WMLs) and lacunar infarcts (LIs) are mostly caused by small vessel disease (SVD). Whereas the main pathomechanism behind LIs is SVD, a variety of mechanisms could be responsible for WMLs. We tried to investigate the relationship between WMLs and LIs and the impact of subtypes of WMLs on its relationship. Methods: We assessed 128 subjects with vascular cognitive impairment with subcortical vascular lesion (VCI-S). LI number and WML volume were determined on T1-, T2-weighted images and fluid-attenuated inversion recovery images using a semiquantitative visual scale. Cognitive function and daily functional impairment were assessed with Mini-Mental State Examination (MMSE) and the Seoul-Instrumental Activities of Daily Living (S-IADL). Results: Of the 128 patients, 106 (82.8%) had Alzheimer’s disease with WML and 22 (17.2%) had subcortical vascular dementia. Seventy patients (54.7%) had at least one lacune. A univariate Poisson model showed that history of hypertension, history of stroke and WML volume (periventricular and deep subcortical) were associated with LIs. A multivariate Poisson model showed that increased WML volume of both types and history of hypertension were associated with LIs. Neither S-IADL score nor MMSE was significantly associated with WML volume of both types. Conclusions: We found that LIs were associated with WMLs regardless of their types in patients with VCI-S. These findings may suggest that periventricular and deep subcortical WMLs share the same vascular pathomechanism of SVD as LIs.
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참고문헌 (24)
참고문헌 신청
[학술지(정기간행물)
Blacker D / 1994 / Reliability and validity of NINCDS-ADRDA criteria for Alzheimer’s disease. The National Institute of Mental Health Genetics Initiative / Arch Neurol 51 :
Breteler MM / 1994 / Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: the Rotterdam Study / Neurology 44 : 1246 ~ 125
Burns JM / 2005 / White matter lesions are prevalent but differentially related with cognition in aging and early Alzheimer disease / Arch Neurol-Chicago 62 : 1870 ~ 1876
Delano-Wood L / 2008 / Regional white matter pathology in mild cognitive impairment - Differential influence of lesion type on neuropsychological functioning / Stroke 39 : 7
Blacker D / 1994 / Reliability and validity of NINCDS-ADRDA criteria for Alzheimer’s disease. The National Institute of Mental Health Genetics Initiative / Arch Neurol 51 :
Breteler MM / 1994 / Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: the Rotterdam Study / Neurology 44 : 1246 ~ 125
Burns JM / 2005 / White matter lesions are prevalent but differentially related with cognition in aging and early Alzheimer disease / Arch Neurol-Chicago 62 : 1870 ~ 1876
Delano-Wood L / 2008 / Regional white matter pathology in mild cognitive impairment - Differential influence of lesion type on neuropsychological functioning / Stroke 39 : 7
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