지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 1 - 16 (16page)
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Objective : In the theory of Korean medicine, Scrophulariae Radix (SR) can clear away heat and cool the blood, nourish yin and promote the production of the body fluids, relieve toxin and benefit the throat. The present study was carried out to investigate effects of SR on allergic contact dermatitis (ACD) induced by 2,4-dinitrochlorobenzene (DNCB) in mice.
Methods : In this experiment, effects of SR on clinical aspects on the skin, histopathological changes such as spongiosis, mast cell distribution, immune cell infiltration in tissue, spleen / body ratio and production levels of serum cytokines were investigated in vivo. In addition, effects on cell viability and release of b-hexosaminidase and histamine were also investigated in vitro.
Results : SR treatment diminished erythema, desquamation and keratosis which were induced by repeated painting of DNCB. Spongiosis and edema were diminished by painting of SR in histopathological observation, infiltrations of mast cell and monocytes were also decreased in SR group. In addition, spleen /body ratio was lowered compared to ADC control group. Production level of IFN-ɤ in serum was decreased, but level of IL-4 did not affected by SR. Finally, more than 400 ㎍/㎖ of SR treatment groups showed decreased cell viabilities in RBL-2H3 cells. Treatment with over 200 ㎍/㎖ of SR decreased b-hexosaminidase release, and treatment with over 400 ㎍/㎖ decreased histamine release in vitro.
Conclusion : these data suggest that SR can decrease symptoms of ACD, then SR is useful to treat patient with ACD.
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참고문헌 (38)
참고문헌 신청
Gunnes G / 2004 / Accumulation of CD25+ CD4+ T-cells in the draining lymph node during the elicitation of DNCB induced contact hypersensitivity in lambs / Research in Veterin
Gutermuth J / 2005 / Model of contact dermatitis and atopic eczema / Drug Discovery Today: Disease Model 2 (2) : 135 ~ 140
Kataranovski M / 2003 / Immunotoxicity of epicutaneously applied anticoagulant rodenticide wafarin : evaluation by contact hypersensitivity to DNCB in rats / Toxicology 188 :
Novak N / 2003 / Immune mechanisms leading to atopic dermatitis / J Allergy Clin Immunol 112 (6) : S128 ~ S139
Okamura T / 2003 / Langerhans-cells in the murine oralmucosa in the inductive phase of delayed type hypersensitivity with 1-chloro- 2, 4-dinitrobenzene / Clin Exp Immunol 134
Gutermuth J / 2005 / Model of contact dermatitis and atopic eczema / Drug Discovery Today: Disease Model 2 (2) : 135 ~ 140
Kataranovski M / 2003 / Immunotoxicity of epicutaneously applied anticoagulant rodenticide wafarin : evaluation by contact hypersensitivity to DNCB in rats / Toxicology 188 :
Novak N / 2003 / Immune mechanisms leading to atopic dermatitis / J Allergy Clin Immunol 112 (6) : S128 ~ S139
Okamura T / 2003 / Langerhans-cells in the murine oralmucosa in the inductive phase of delayed type hypersensitivity with 1-chloro- 2, 4-dinitrobenzene / Clin Exp Immunol 134
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