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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 78 - 85 (8page)
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초록· 키워드
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Background and Objectives : The aim of this study was to investigate anti-inflammatory and anti-oxidant effects of Hyunggaeyungyo-tang(HYT) on RAW 264.7 cells.
Material and Methods : Two types of experiments were implemented for this study: first, the experiment to study the anti-oxidant effect of HYT using riboflavin; second, in vitro experiment to investigate the suppression of NF-κB activation using RAW 264.7 cells (IκB kinase and induce nitric oxide synthase mRNA expression)Results : 1. The anti-oxidant effects of HYT was dose-dependantly increased.
2. The RAW 264.7cells were treated with LPS for 1 hours prior to the addition of indicated concentrations(0.4,-1.0㎎/㎖) of HYT, and the cells were further incubated for 24 hours. The LPS-induced IKK & iNOS mRNA expression were dose-dependantly decreased in HYT treated RAW 264.7cells.
Conclusion : The results suggest that HYT is significantly effective in the treatment of inflammation through the suppression of NF-κB activation and iNOS production.
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참고문헌 (28)
참고문헌 신청
?廷賢 / 1994 / 增補萬病回春 下卷 / 일중사 : 12 ~
Ai-Hsiang LO / 2002 / Carnosol, an antioxidant in rosemary,suppresses inducible nitric oxide synthase through down-regulating NF-κB in mouse macrophages / Carcinogenesis 23
Eiserich JP / 2001 / Freeman BA.Myeloperoxidase, a leukocyte-derived vascular NO oxidase / Science 296 (5577) : 2391 ~ 2394
Floyd RA / 1999 / Neuroinflammatory processes are important in neurodegenerative diseases: an hypothesis to explain the increased formation of reactive oxygen and nitrogen s
Guzik TJ / 2000 / Vascular superoxide production by NAD (P)H oxidase: association with endothelial dysfunction and clinical risk factors / Circ Res 86 (9) : 85 ~ 90
Ai-Hsiang LO / 2002 / Carnosol, an antioxidant in rosemary,suppresses inducible nitric oxide synthase through down-regulating NF-κB in mouse macrophages / Carcinogenesis 23
Eiserich JP / 2001 / Freeman BA.Myeloperoxidase, a leukocyte-derived vascular NO oxidase / Science 296 (5577) : 2391 ~ 2394
Floyd RA / 1999 / Neuroinflammatory processes are important in neurodegenerative diseases: an hypothesis to explain the increased formation of reactive oxygen and nitrogen s
Guzik TJ / 2000 / Vascular superoxide production by NAD (P)H oxidase: association with endothelial dysfunction and clinical risk factors / Circ Res 86 (9) : 85 ~ 90
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