小葉麥門冬이 NC/Nga 아토피모델에 미치는 영향

장성은; 김윤범

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저자정보: 장성은 김윤범

저널정보: 대한한방안이비인후피부과학회 한방안이비인후피부과학회지 한방안이비인후피부과학회지 제21권 제3호

발행연도: 2008.1

수록면: 10 - 19 (10page)

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Objective : To investigate the effects of Radix Ophiopogon japonicus on atopic dermatitis, I prepared DNCB(2,4-dinitrochlorobenzen) induced atopic dermatitis NC/Nga mice and observed the mice by four ways; eye observation, the number of skin behavior times, histological changes of skin and cytokine(Total IgE, IL-4, IFN-γ). Methods : After prepare Radix Ophiopogon japonicus extract, DNCB induced atopic dermatitis NC/Nga mice were divided into three groups. The first is Control group which was intact group. The second is Medication group which was orally medicated Radix Ophiopogon japonicus extract one time a day for consecutive 5 days. The third group is Application group which was applied Radix Ophiopogon japonicus extract externally one time a day for consecutive 5 days. After that, the effect of Radix Ophiopogon japonicus on atopic dermatitis was observed. Statistical analysis was performed by using Kruskal-Wallis test and statistical significance was set at less than 5%. Results : 1. At observation of skin morphologic change, Radix Ophiopogon japonicus showed some effects to prevent erythema reaction on skin in both Medication group and Application group. 2. At the number of scratching behavior times, Radix Ophiopogon japonicus showed an effect to decrease scratching behavior times, but there was no statistical significance among three groups. 3. At skin tissue H-E stain, Radix Ophiopogon japonicus showed an effect to prevent skin epidermal tissue damages and also showed that it could keep the skin healthy in both Medication group and Application group. Especially in Application group, the skin of mouse showed almost normal recovery. 4. At cytokines, there was no statistical significance among three groups in IgE and IL-4. But Radix Ophiopogon japonicus showed an significant effect to suppress IFN-γ in both Medication group and Application group. There was no significant difference between two groups. Conclusion : Radix Ophiopogon japonicus has some effects on atopic dermatitis in both internal medication and external application.

Objective : To investigate the effects of Radix Ophiopogon japonicus on atopic dermatitis, I prepared DNCB(2,4-dinitrochlorobenzen) induced atopic dermatitis NC/Nga mice and observed the mice by four ways; eye observation, the number of skin behavior times, histological changes of skin and cytokine(Total IgE, IL-4, IFN-γ). Methods : After prepare Radix Ophiopogon japonicus extract, DNCB induced atopic dermatitis NC/Nga mice were divided into three groups. The first is Control group which was intact group. The second is Medication group which was orally medicated Radix Ophiopogon japonicus extract one time a day for consecutive 5 days. The third group is Application group which was applied Radix Ophiopogon japonicus extract externally one time a day for consecutive 5 days. After that, the effect of Radix Ophiopogon japonicus on atopic dermatitis was observed. Statistical analysis was performed by using Kruskal-Wallis test and statistical significance was set at less than 5%. Results : 1. At observation of skin morphologic change, Radix Ophiopogon japonicus showed some effects to prevent erythema reaction on skin in both Medication group and Application group. 2. At the number of scratching behavior times, Radix Ophiopogon japonicus showed an effect to decrease scratching behavior times, but there was no statistical significance among three groups. 3. At skin tissue H-E stain, Radix Ophiopogon japonicus showed an effect to prevent skin epidermal tissue damages and also showed that it could keep the skin healthy in both Medication group and Application group. Especially in Application group, the skin of mouse showed almost normal recovery. 4. At cytokines, there was no statistical significance among three groups in IgE and IL-4. But Radix Ophiopogon japonicus showed an significant effect to suppress IFN-γ in both Medication group and Application group. There was no significant difference between two groups. Conclusion : Radix Ophiopogon japonicus has some effects on atopic dermatitis in both internal medication and external application.

#Atopic dermatitis #Radix Ophiopogon japonicus #Scratching behavior #IgE #IL-4 #IFN-γ

참고문헌 (26)

참고문헌 신청

Dai HF / 2005 / A New Steroidal Glycoside from Ophiopogon japonicus(Thumb) Ker-Gawl / J. of Integrative Plant Biology 47 (9) : 1148 ~ 52

Hoang Anh NT / 2003 / Homoisoflavonoids from Ophiopogon japonicus Ker-Gawler / Phytochemistry (62) : 1153 ~ 8

Jinyoung Hur / 2004 / Dual Neurotrophic Effects of Steroidal Saponin Derivative, Spicatoside A, Isolated from Liriope platyphylla:stimulation of NGF synthesis and activation

Kou J / 2005 / Anti-inflammatory Activities of Aqueous Extract from Radix Ophiopogon japonicus and Its Two Constituents / Biol. Pharm. Bull 28 (7) : 1234 ~ 8

Leung DY / 2001 / Cellular and immunologic mechanisms in atopic dermatitis / J Am Acad Dermatol 44 (1) : S1 ~ S12

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