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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 79 - 90 (12page)
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초록· 키워드
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Objectives : This study was carried out to evaluate the repeated dose oral toxicity of Alismatis Rhizoma inSprague-Dawley(SD) rats.
Methods : Male and female rats were administered orally with Alismatis Rhizoma water extract of 500 ㎎/㎏(lowdosage group), 1,000 ㎎/㎏(middle dosage group) and 2,000 ㎎/㎏(high dosage group). We daily observed numberof deaths, clinical signs and gross findings for 14 days(twice a day). After 14 days, we measured body and organsweight. Also we analyzed hematological changes.
Results : No dead SD rats and no clinical signs were found during the experiment period. Also other specificchanges were not found between control and treated groups in hematology and serum biochemistry. In additionno significant changes of gross body and individual organs weight.
Conclusions : These results suggest that water soluble extract of Alismatis Rhizoma has not repeated dose oraltoxicity and oral LD50 value was over 2,000 ㎎/㎏ in SD rats. As a result, we can determine Alismatis Rhizoma isa relatively safe substance.
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참고문헌 (17)
참고문헌 신청
Chang IM / 2002 / Current trend of natural products industry and utilization of herbal materials / Korean journal of crop science 47 (1) : 28 ~ 37
Duan XY / 2004 / A 60 day feeding study of Rhizoma Alismatis Orientalis in SD rats / Chinese Journal of Food Hygiene 16 (2) : 108 ~ 111
Ha HY / 2007 / The another name of herbal medicine 1 / passanpass : 461 ~ 462
Hu XM / 1998 / Zhonghwabencao Jingxuanben 1 / kejichubanshe : 1991 ~ 1998
Kim KS / 1999 / Present Status and Perspectives of Medicinal Plant Resources in Korea / Research of national Resources 2 : 25 ~ 41
Duan XY / 2004 / A 60 day feeding study of Rhizoma Alismatis Orientalis in SD rats / Chinese Journal of Food Hygiene 16 (2) : 108 ~ 111
Ha HY / 2007 / The another name of herbal medicine 1 / passanpass : 461 ~ 462
Hu XM / 1998 / Zhonghwabencao Jingxuanben 1 / kejichubanshe : 1991 ~ 1998
Kim KS / 1999 / Present Status and Perspectives of Medicinal Plant Resources in Korea / Research of national Resources 2 : 25 ~ 41
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