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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 51 - 61 (11page)
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초록· 키워드
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Objective : This research has been conducted to comparative analysis of anti-inflammatory effects to suggest a usefulness of ethanol extracts from Gentianae sino-ornata (GSO) as a functional material for inflammatory activities.
Methods : Cell viability was measured by neutral red (NR) assay, and nitric oxide (NO) production in RAW264.7 cells was monitored by measuring the nitrite content in culture medium. The expressions of cyclooxigenase-2 (COX-2) was determined by western blot analysis, and Inducible nitric oxide syntase (iNOS) and cytokine were determined by reverse transcriptase-polymerase chain reaction (RT-PCR).
Results : When the GSO extract was added the concentration of 5-20 ㎍/㎕, the viability of cells was maintained 90% or more at all levels. NO production was suppressed by the treatment of GSO in LPS-stimulated RAW264.7 cells. GSO inhibited the expression of iNOS, COX-2, IL-1β and IL-6 in LPS-stimulated RAW264.7 cells.
Conclusions: From this results, we consider that GSO can be a useful therapeutic and preventive approach to various inflammatory diseases as a functional material for inflammatory activities.
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등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Abreu MT / 2004 / Innate immunity and toll-like receptors: clinical implications of basic science research / J. Pediatr 144 : 421 ~ 429
Abul K / 2006 / Celluar and Molecular Immunology / Saunders Elsevier : 75 ~ 97
Barton CC / 2001 / Bacterial lipopolysaccharide enhances aflatoxin B1 hepatotoxicity in rats by a mechanism that depends on tumor necrosis factor-α / Hepatology 33 : 66 ~ 73
Bhattacharyya A / 2002 / Mitogenactivated protein kinases and NF-kappaB regulate H. pylori-mediated IL-8releasefrom macrophages / Biochem J 366 : 376 ~ 382
Borenfreund E / 1984 / Toxicity determined in vitro by morphological alterations and neutral red absorption / Toxicol Lett 24 (2-3) : 119 ~ 124
Abul K / 2006 / Celluar and Molecular Immunology / Saunders Elsevier : 75 ~ 97
Barton CC / 2001 / Bacterial lipopolysaccharide enhances aflatoxin B1 hepatotoxicity in rats by a mechanism that depends on tumor necrosis factor-α / Hepatology 33 : 66 ~ 73
Bhattacharyya A / 2002 / Mitogenactivated protein kinases and NF-kappaB regulate H. pylori-mediated IL-8releasefrom macrophages / Biochem J 366 : 376 ~ 382
Borenfreund E / 1984 / Toxicity determined in vitro by morphological alterations and neutral red absorption / Toxicol Lett 24 (2-3) : 119 ~ 124
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