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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 54 - 64 (11page)
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Objectives : Stevia rebaudiana is a well-known herbal sweetener in the Korea, Japan and China, and its medical uses were originated from countries in South America. Although it has been shown the various medical effects of S. rebaudiana including contraception and treatment of human diseases such as hyperglycemia, it has almost not been studied about the efficacy of S. rebaudiana methanolic extract (SRE) on the acute inflammation and its action mechanism.
Methods : To investigate the anti-inflammatory effects of SRE, we treated SRE and examined the level of inflammatory mediators in LPS-stimulated Raw264.7 cells.
Results : Treatment of macrophage with LPS markedly induced the production of NO, PGE2 and pro-inflammatory cytokines. Pretreatment of SRE blocked the induction of inflammatory mediators and the expression of iNOS protein. More importantly, LPS-induced phosphorylation of IκB-α was suppressed by the treatment of SRE,suggesting SRE inhibition of NF-κB activation. Furthermore, SRE blocked LPS-induced phosphorylation of MAPKs.
Conclusions : SRE inhibited the induction of NO, PGE2 and pro-inflammatory cytokines in Raw264.7 cells. SRE's effect may be mediated with its inhibition of NF-κB activation and MAPK phosphorylation, which suggests its uses as an anti-inflammatory agents.
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참고문헌 (25)
참고문헌 신청
Chan P / 1998 / The effect of stevioside on blood pressure and plasma catecholamines in pontaneously hypertension rats / Life Sci 19 : 1679 ~ 1684
Dacome AS / 2005 / Sweet diterpenic glycoside balance of a new cultivar of Stevia rebaudiana (Bert.) Bertoni: isolation and quantitative distribution by chromatography, spec
Dong C / 2002 / MAP kinases in the immune response / Annu Rev Immuno 20 : 55 ~ 72
Dyrskog SE / 2005 / Preventive effects of soy based diet supplemented with stevioside on development of type 2 diabetes / Metabolism 54 : 1181 ~ 1188
Johnson GL / 2002 / Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases / Science 298 : 1911 ~ 1912
Dacome AS / 2005 / Sweet diterpenic glycoside balance of a new cultivar of Stevia rebaudiana (Bert.) Bertoni: isolation and quantitative distribution by chromatography, spec
Dong C / 2002 / MAP kinases in the immune response / Annu Rev Immuno 20 : 55 ~ 72
Dyrskog SE / 2005 / Preventive effects of soy based diet supplemented with stevioside on development of type 2 diabetes / Metabolism 54 : 1181 ~ 1188
Johnson GL / 2002 / Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases / Science 298 : 1911 ~ 1912
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