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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,604 - 1,612 (9page)
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Purpose: Adiponectin is expressed in adipose tissue, and is affected by smoking, obesity, and genetic factors, such as CDH13 polymorphism,contributing to the development of coronary vascular diseases (CVDs).
Materials and Methods: We investigated the effect of genetic variations of CDH13 (rs3865188) on blood chemistry and adiponectinlevels in 345 CVD patients undergoing statin-free or statin treatment.
Results: Genetic variation in CDH13 was significantly correlated with several clinical factors, including adiponectin, diastolic blood pressure, triglyceride (TG), and insulin levels. Subjects with the T allele (mutant form) had significantly lower adiponectin levels than those with the A allele. Total cholesterol (TC), low-density lipoprotein cholesterol (LDLc), TG/high-density lipoprotein cholesterol(HDLc) ratio, and HDL3b subtype were markedly decreased in statin treated subjects regardless of having the A or T allele. TG and TG/HDL in the statin-free group with TT genotype of the rs3865188 was higher than in the others but they were not differentin the statin-treated subjects. We observed a significant difference in adiponectin levels between patients with the A and T alleles in the statin-free group; meanwhile, no difference in adiponectin levels was noted in the statin group. Plasma levels of other cytokines, leptin, visfatin, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), were not different among the CDH13 genotypes according to statin administration. Body mass index (BMI), TG, insulin, HDL3b, and TG/HDL ratio showed negative correlations with adiponectin levels.
Conclusion: Plasma adiponectin levels and TG/HDL ratio were significantly different according to variants of CDH13 and statin administration in Korean patients with CVD.
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참고문헌 (33)
참고문헌 신청
Gao H / 2013 / Genetic variation in CDH13 is associated with lower plasma adiponectin levels but greater adiponectin sensitivity in East Asian populations / Diabetes 62:4277~4283
Matsubara M / 2002 / Decreased plasma adiponectin concentrations in women with dyslipidemia / J Clin Endocrinol Metab 87:2764~2769
Song B / 2014 / Association between statin use and short-term outcome based on severity of ischemic stroke: a cohort study / PLoS One 9:e84389
Zhou Q / 2013 / Simvastatin pharmacokinetics in healthy Chinese subjects and its relations with CYP2C9, CYP3A5, ABCB1, ABCG2 and SLCO1B1 polymorphisms / Pharmazie 68:124~128
Lobo SM / 2012 / TNF-α modulates statin effects on secretion and expression of MCP-1, PAI-1 and adiponectin in 3T3-L1 differentiated adipocytes / Cytokine 60:150~156
Matsubara M / 2002 / Decreased plasma adiponectin concentrations in women with dyslipidemia / J Clin Endocrinol Metab 87:2764~2769
Song B / 2014 / Association between statin use and short-term outcome based on severity of ischemic stroke: a cohort study / PLoS One 9:e84389
Zhou Q / 2013 / Simvastatin pharmacokinetics in healthy Chinese subjects and its relations with CYP2C9, CYP3A5, ABCB1, ABCG2 and SLCO1B1 polymorphisms / Pharmazie 68:124~128
Lobo SM / 2012 / TNF-α modulates statin effects on secretion and expression of MCP-1, PAI-1 and adiponectin in 3T3-L1 differentiated adipocytes / Cytokine 60:150~156
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