지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 854 - 864 (11page)
이용수
초록· 키워드
오류제보하기
Purpose: The main objective of this study was to evaluate the association between polymorphisms of the target genes of pemetrexed and clinical outcomes in non-small cell lung cancer (NSCLC) patients treated with pemetrexed. Materials and Methods: We assessed polymorphisms at 8 sites in 4 genes [thymidylate synthase (TS), dihydrofolate reductase (DHFR; 1610, 680, 317, intron 1), methylenetetrahydrofolate reductase (MTHFR; 677, 1298), glycinamide ribonucleotide formyl transferase (GARFT; 2255)] associated with pemetrexed metabolism using polymerase chain reaction, gene scanning, and restriction fragment length polymorphism analysis in 90 patients with adenocarcinoma of the lung. Results: Survival was significantly longer with pemetrexed in patients with TS 3RGCC/3RGCC or 3RGGC/3RGGC compared with the other groups (PFS; 5.2 months vs. 3.7 months, p=0.03: OS; 31.8 months vs. 18.5 months, p=0.001). Patients with DHFR 680CC experienced fatigue more frequently (50% vs. 8.6%, p=0.008). Polymorphisms of MTHFR and GARFT were not significantly associated with clinical outcomes of pemetrexed. Conclusion: The TS genotype was associated with survival and one DHFR polymorphism was associated with fatigue in NSCLC patients treated with pemetrexed. Further large prospective studies are required to identify other biomarkers that affect patients being treated with pemetrexed for adenocarcinoma of the lung.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Adjei AA / 2004 / Pemetrexed (ALIMTA), a novel multitargeted antineoplastic agent / Clin Cancer Res 10 (12) : 4276s ~ 4280s
Berkun Y / 2004 / Methotrexate related adverse effects in patients with rheumatoid arthritis are associated with the A1298C polymorphism of the MTHFR gene / Ann Rheum Dis 63
Boom R / 1990 / Rapid and simple method for purification of nucleic acids / J Clin Microbiol 28 : 495 ~ 503
Ceppi P / 2006 / Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase / Cancer 107 : 158
Curtin NJ / 2001 / Pemetrexed disodium, a novel antifolate with multiple targets / Lancet Oncol 2 : 298 ~ 306
Berkun Y / 2004 / Methotrexate related adverse effects in patients with rheumatoid arthritis are associated with the A1298C polymorphism of the MTHFR gene / Ann Rheum Dis 63
Boom R / 1990 / Rapid and simple method for purification of nucleic acids / J Clin Microbiol 28 : 495 ~ 503
Ceppi P / 2006 / Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase / Cancer 107 : 158
Curtin NJ / 2001 / Pemetrexed disodium, a novel antifolate with multiple targets / Lancet Oncol 2 : 298 ~ 306
이 논문의 저자 정보
최근 본 자료
댓글(0)
0