지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 587 - 592 (6page)
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Purpose: Tubulointerstitial hypoxia in the kidney is considered a hallmark of injury and a mediator of the progression of tubulointerstitial fibrosis. Hypoxia-inducible factor-1alpha (HIF-1alpha), a master transcription factor in cellular adaptation to hypoxia,regulates a wide variety of genes, some of which are closely associated with tissue fibrosis. The present study set out to characterize urinary HIF-1alpha expressions in patients with lupus nephritis (LN) and to explore whether urinary HIF-1alpha expressions are associated with histologic chronicity changes and renal function. Materials and Methods: Urinary HIF-1alpha levels were measured by enzyme-linked immunosorbent assays in 42 patients with LN and in 30 healthy controls. Activity and chronicity indexes as well as tubular HIF-1alpha expressions were analyzed for each specimen. Results: Urinary HIF-1alpha levels were higher in LN patients than in healthy controls (3.977±1.696 vs. 2.153±0.554 ng/mL, p<0.001) and were associated with histologic chronicity indexes (r=0.463, p<0.01) and eGFR (r=-0.324, p<0.05). However, urinary HIF-1alpha levels showed no correlation with histologic activity indexes, anti-dsDNA, ANA, complement 3 and 4 levels, proteinuria, systemic lupus erythematosis disease activity index, and WHO pathological classification (p>0.05). Conclusion: Urinary HIF-1alpha levels were elevated in LN patients and were associated with histologic chronicity changes and renal function, indicating that HIF-1alpha might contribute to histologic chronicity in LN.
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참고문헌 (25)
참고문헌 신청
Austin HA 3rd / 1983 / Prognostic factors in lupus nephritis. Contribution of renal histologic data / Am J Med 75 : 382 ~ 391
Bagavant H / 2009 / Pathogenesis of kidney disease in systemic lupus erythematosus / Curr Opin Rheumatol 21 : 489 ~ 494
Eckardt KU / 2005 / Rosenberger C, Wiesener MS, et al. Role of hypoxia in the pathogenesis of renal disease / Kidney Int Suppl : S46 ~ S51
Fine LG / 2000 / Is there a common mechanism for the progression of different types of renal diseases other than proteinuria? Towards the unifying theme of chronic hypoxia /
Fine LG / 2008 / Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics / Kidney Int 74 : 867 ~ 872
Bagavant H / 2009 / Pathogenesis of kidney disease in systemic lupus erythematosus / Curr Opin Rheumatol 21 : 489 ~ 494
Eckardt KU / 2005 / Rosenberger C, Wiesener MS, et al. Role of hypoxia in the pathogenesis of renal disease / Kidney Int Suppl : S46 ~ S51
Fine LG / 2000 / Is there a common mechanism for the progression of different types of renal diseases other than proteinuria? Towards the unifying theme of chronic hypoxia /
Fine LG / 2008 / Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics / Kidney Int 74 : 867 ~ 872
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