지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 578 - 586 (9page)
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Purpose: In patients with diabetic end stage renal disease (ESRD), glycated albumin (GA) reflects recent glycemic control more accurately than glycated hemoglobin (HbA1c). We evaluated the relationship between GA and average blood glucose (AG) level and developed an estimating equation for translating GA values into easier-to-understand AG levels. Materials and Methods: A total of 185 ESRD patients, including 154 diabetic and 31 non-diabetic participants, were enrolled (108 hemodialysis, 77 peritoneal dialysis). Patients were asked to perform four-point daily self-monitoring of capillary blood glucose (SMBG) at least three consecutive days each week for four weeks. Serum levels of GA, HbA1c and other biochemical parameters were checked at baseline, as well as at 4 and 8 weeks. Results:Approximately 74.3±7.0 SMBG readings were obtained from each participant and mean AG was 169.1±48.2 mg/dL. The correlation coefficient between serum GA and AG levels (r=0.70, p<0.001) was higher than that of HbA1c and AG (r=0.54, p<0.001). Linear regression analysis yielded the following equation: estimated AG (eAG) (mg/dL)=4.71×GA%+73.35, and with this formula, serum GA levels could be easily translated to eAG levels. Multivariate analysis revealed significant contributions of postprandial hyperglycemia (β=0.25, p=0.03) and serum albumin (β=0.17, p=0.04) in determining serum GA level, independent to other clinical parameters. Conclusion: Compared to HbA1c, serum GA levels were better correlated with AG levels. Using the estimating equation, an average blood glucose level of 155-160 mg/dL could be matched to a GA value of 18-19% in patients with ESRD.
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참고문헌 (22)
참고문헌 신청
ADVANCE Collaborative Group / 2008 / Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes / N Engl J Med 358 : 2560 ~ 2572
American Diabetes Association / 2007 / Standards of medical care in diabetes-- 2007 / Diabetes Care 30 (Suppl 1) : 4 ~ 41
Chujo K / 2006 / Indicators for blood glucose control in diabetics with end-stage chronic renal disease: GHb vs. glycated albumin (GA) / J Med Invest 53 : 223 ~ 228
Freedman BI / 2010 / Comparison of glycated albumin and hemoglobin A1c concentrations in diabetic subjects on peritoneal and hemodialysis / Perit Dial Int 30 : 72 ~ 79
Fukuoka K / 2008 / Glycated albumin levels predict long-term survival in diabetic patients undergoing haemodialysis / Nephrology 13 : 278 ~ 283
American Diabetes Association / 2007 / Standards of medical care in diabetes-- 2007 / Diabetes Care 30 (Suppl 1) : 4 ~ 41
Chujo K / 2006 / Indicators for blood glucose control in diabetics with end-stage chronic renal disease: GHb vs. glycated albumin (GA) / J Med Invest 53 : 223 ~ 228
Freedman BI / 2010 / Comparison of glycated albumin and hemoglobin A1c concentrations in diabetic subjects on peritoneal and hemodialysis / Perit Dial Int 30 : 72 ~ 79
Fukuoka K / 2008 / Glycated albumin levels predict long-term survival in diabetic patients undergoing haemodialysis / Nephrology 13 : 278 ~ 283
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