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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 753 - 760 (8page)
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Purpose: Combined hepatocellular-cholangiocarcinoma (CHCC) is an uncommon form of cancer, and its clinicopathological features have rarely been reported in detail.
This study was undertaken to evaluate the clinicopathological characteristics and prognostic factors of CHCC. Materials and Methods: The clinicopathological features of patients diagnosed with CHCC at Severance Hospital between January 1996 and December 2007 were retrospectively studied by comparing them with the features of patients with hepatocellular carcinoma (HCC) or cholangiocarcinoma (CC) who had undergone a hepatic resection during the same period. Results: Forty-three patients diagnosed with CHCC were included in this study (M : F=35 : 8, median age, 55 years). According to the parameters of the American Joint Committee on Cancer staging, there were 6 (14.0%), 9 (20.9%), 25 (58.1%), and 3 (7.0%) patients with stages I, II, III, and IV cancer, respectively. Thirty-two of the 43 patients underwent resection with curative intent. After resection, 27 patients (84.4%) had tumor recurrence during the follow-up period of 18 months (range: 6-106 months), and the median time to recurrence was 13 months. Overall median survival periods after hepatic resection of CHCC, HCC and CC were 34, 103 and 38.9 months, respectively (p<0.001). The median overall survival for all patients with CHCC was 21 months, and the 5-year survival rate was 18.1%. The presence of portal vein thrombosis and distant metastasis were independent prognostic factors of poor survival. Conclusion: Even after curative hepatic resection, the presence of a cholangiocellular component appeared to be a poor prognostic indicator in patients with primary liver cancer.
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참고문헌 (21)
참고문헌 신청
ALLEN RA / 1949 / Combined liver cell and bile duct carcinoma / Am J Pathol 25 : 647 ~ 655
Bhagat V / 2006 / Combined hepatocholangiocarcinoma: case-series and review of literature / Int J Gastrointest Cancer 37 : 27 ~ 34
Chantajitr S / 2006 / Combined hepatocellular and cholangiocarcinoma: clinical features and prognostic study in a Thai population / J Hepatobiliary Pancreat Surg 13 : 537 ~
Choi SB / 2009 / The Prognosis and Survival Outcome of Intrahepatic Cholangiocarcinoma Following Surgical Resection: Association of Lymph Node Metastasis and Lymph Node Disse
Gibson JB / 1978 / Histological typing of tumours of the liver, biliary tract, and pancreas / World Health Organization
Bhagat V / 2006 / Combined hepatocholangiocarcinoma: case-series and review of literature / Int J Gastrointest Cancer 37 : 27 ~ 34
Chantajitr S / 2006 / Combined hepatocellular and cholangiocarcinoma: clinical features and prognostic study in a Thai population / J Hepatobiliary Pancreat Surg 13 : 537 ~
Choi SB / 2009 / The Prognosis and Survival Outcome of Intrahepatic Cholangiocarcinoma Following Surgical Resection: Association of Lymph Node Metastasis and Lymph Node Disse
Gibson JB / 1978 / Histological typing of tumours of the liver, biliary tract, and pancreas / World Health Organization
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