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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 595 - 602 (8page)
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Purpose: Cardiac troponin T (cTnT), a useful marker for diagnosing acute myocardial infarction (AMI) in the general population, is significantly higher than the usual cut-off value in many end-stage renal disease (ESRD) patients without clinically apparent evidence of AMI. The aim of this study was to evaluate the clinical usefulness of cTnT in ESRD patients with acute coronary syndrome (ACS). Materials and Methods: Two hundred eighty-four ESRD patients with ACS were enrolled between March 2002 and February 2008. These patients were followed until death or June 2009. Medical records were reviewed retrospectively. The cut-off value of cTnT for AMI was evaluated using a receiver operating characteristic (ROC) curve. We calculated Kaplan-Meier survival curves, and potential outcome predictors were determined by Cox proportional hazard analysis. Results: AMIs were diagnosed in 40 patients (14.1%). The area under the curve was 0.98 in the ROC curve (p<0.001; 95% CI, 0.95-1.00). The summation of sensitivity and specificity was highest at the initial cTnT value of 0.35 ng/mL (sensitivity, 0.95; specificity,0.97). Survival analysis showed a statistically significant difference in all-cause and cardiovascular mortalities for the group with an initial cTnT ≥0.35 ng/mL compared to the other groups. Initial serum cTnT concentration was an independent predictor for mortality. Conclusion: Because ESRD patients with an initial cTnT concentration ≥0.35 ng/mL have a poor prognosis, it is suggested that urgent diagnosis and treatment be indicated in dialysis patients with ACS when the initial cTnT levels are ≥0.35 ng/mL.
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참고문헌 (21)
참고문헌 신청
Alpert JS / 2000 / Myocardial infarction redefined--a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefin
Apple FS / 1997 / Prognostic value of serum cardiac troponin I and T in chronic dialysis patients: a 1-year outcomes analysis / Am J Kidney Dis 29 :
Apple FS / 2002 / European Society of Cardiology and American College of Cardiology guidelines for redefinition of myocardial infarction: how to use existing assays clinical
Apple FS / 2002 / Predictive value of cardiac troponin I and T for subsequent death in end-stage renal disease / Circulation 106 : 2941 ~ 2945
Aviles RJ / 2002 / Troponin T levels in patients with acute coronary syndromes, with or without renal dysfunction / N Engl J Med 346 : 2247 ~ 2052
Apple FS / 1997 / Prognostic value of serum cardiac troponin I and T in chronic dialysis patients: a 1-year outcomes analysis / Am J Kidney Dis 29 :
Apple FS / 2002 / European Society of Cardiology and American College of Cardiology guidelines for redefinition of myocardial infarction: how to use existing assays clinical
Apple FS / 2002 / Predictive value of cardiac troponin I and T for subsequent death in end-stage renal disease / Circulation 106 : 2941 ~ 2945
Aviles RJ / 2002 / Troponin T levels in patients with acute coronary syndromes, with or without renal dysfunction / N Engl J Med 346 : 2247 ~ 2052
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