지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 581 - 587 (7page)
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Purpose: Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation of the airways and progressive destruction of lung parenchyma.
Apoptosis is critical for the maintenance of normal tissue homeostasis and is in equilibrium with proliferation and differentiation. This study was undertaken to investigate relationship between apoptosis of peripheral blood lymphocytes during exacerbation of COPD and inflammatory response that characterizes this condition. Materials and Methods: Seventeen patients with COPD exacerbation,21 stable COPD, and 12 control subjects were included. T lymphocytes were isolated from peripheral blood using MACS. Apoptosis of T lymphocytes was assessed with FACS using annexin V and 7-aminoactinomycin. Serum levels of interleukin (IL)-6, IL-8 and tumor necrosis factor (TNF)-α were determined by an immunoassay technique. Results: There was significantly increased percentage of apoptotic lymphocytes, CD 4^+, and CD 8^+ T cells in the peripheral blood of patients with exacerbation of COPD compared with stable COPD. Serum levels of IL-6, IL-8, and TNF-α were significantly increased in patients with exacerbation of COPD compared with stable COPD. Only TNF-α presented a positive correlation with apoptotic lymphocytes in patients with exacerbation of COPD. Conclusion: Increased apoptotic lymphocytes may be associated with upregulation of TNF-α in the peripheral blood of patients with acute exacerbation of COPD.
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참고문헌 (24)
참고문헌 신청
Anthonisen NR / 1987 / Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease / Ann Intern Med 106 : 196 ~ 204
Barnes PJ / 2003 / Chronic obstructive pulmonary disease: molecular and cellular mechanisms / Eur Respir J 22 : 672 ~ 688
Bhowmik A / 2000 / Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations / Thorax 55 : 114 ~ 120
Biffl WL / 1995 / Interleukin-6 suppression of neutrophil apoptosis is neutrophil concentration dependent / J Leukoc Biol 58 : 582 ~ 584
Crooks SW / 2000 / Bronchial inflammation in acute bacterial exacerbations of chronic bronchitis: the role of leukotriene B4 / Eur Respir J 15 : 274 ~ 280
Barnes PJ / 2003 / Chronic obstructive pulmonary disease: molecular and cellular mechanisms / Eur Respir J 22 : 672 ~ 688
Bhowmik A / 2000 / Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations / Thorax 55 : 114 ~ 120
Biffl WL / 1995 / Interleukin-6 suppression of neutrophil apoptosis is neutrophil concentration dependent / J Leukoc Biol 58 : 582 ~ 584
Crooks SW / 2000 / Bronchial inflammation in acute bacterial exacerbations of chronic bronchitis: the role of leukotriene B4 / Eur Respir J 15 : 274 ~ 280
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