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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 891 - 900 (10page)
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초록· 키워드
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Chondrogenesis involves the recruitment of mesenchymal cells to differentiate into chondroblasts, and also the cells must synthesize a cartilage-specific extracellular matrix. There were two representative culture systems that promoted the chondrogenic differentiation of human mesenchymal stem cells. These systems were adaptations of the “pellet” culture system, which was originally described as a method for preventing the phenotypic modulation of chondrocytes, and the “alginate bead” culture system, which was used to maintain encapsulated cells at their differentiated phenotype over time, and also it was used to maintain the cells' proteoglycan synthesis at a rate similar to that of primary chondrocytes. We performed test on the differences of phenotypic characterization with the two methods of differentiating human mesenchymal stem cells into chondrocytes. The typical gene for articular cartilage, collagen type II, was more strongly expressed in the “alginate bead” system than in the “pellet” culture system, in addition, specific gene for hypertrophic cartilage, collagen type X, was more rapidly expressed in the “pellet” system than in “alginate bead” culture system. Therefore, the “alginate bead” culture system is a more phenotypical, practical and appropriate system to differentiate human mesenchymal stem cells into articular chondrocytes than the “pellet” culture system.
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참고문헌 (27)
참고문헌 신청
/ 1994 / Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage 76 : 579 ~ 592
/ 1994 / Thyroxine is the serum factor that regulates morphogenesis of columnar cartilage from isolated chondrocytes in chemically defined medium 126 : 1311 ~ 1318
/ 1995 / Osteoblast and chondroblast differentiation 17 : S77 ~ 83
/ 1995 / The monoclonal antibody SH-2, raised against human mesenchymal stem cells, recognizes an epitope on endoglin (CD105) 265 : 134 ~ 139
/ 1996 / Adult human chondrocytes cultured in alginate form a matrix similar to native human articular cartilage 271 : C742 ~ 752
/ 1994 / Thyroxine is the serum factor that regulates morphogenesis of columnar cartilage from isolated chondrocytes in chemically defined medium 126 : 1311 ~ 1318
/ 1995 / Osteoblast and chondroblast differentiation 17 : S77 ~ 83
/ 1995 / The monoclonal antibody SH-2, raised against human mesenchymal stem cells, recognizes an epitope on endoglin (CD105) 265 : 134 ~ 139
/ 1996 / Adult human chondrocytes cultured in alginate form a matrix similar to native human articular cartilage 271 : C742 ~ 752
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