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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 227 - 234 (8page)
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Purpose: The aim of the present study was to investigate associations between the renin gene (REN) and the risk of essential hypertension and blood pressure (BP) levelsin Koreans. Materials and Methods: To outline the functional role of a single nucleotide polymorphism in the transcription of the REN gene, we conducted a case-control study of 1975 individuals: 646 hypertension (HT) patients and 1329 ethnicallyand age-matched normotensive subjects. Results: Logistic regression analysis indicatedthat the genotypes AA/AG were strongly associated with risk of HT (odds ratio, 1.493; 95% confidence interval, 1.069‒2.086, p=0.018) in female subjects. The genotypes AA/AG also showed significant association with higher blood pressure levels, both systolic and diastolic, in postmenopausal HT women (p=0.003 and p=0.017, respectively). Analysis of the promoter containing rs6682082 revealed a 2.4±0.01-fold higher activity in the A variant promoter than the G variant promoter,suggesting that rs6682082 is itself a functional variant. Conclusion: We suggestthat the A allele of rs6682082 is a positive genetic marker for predisposition to essential hypertension and high BP in Korean women and may be mediated through the transcriptional activation of REN.
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참고문헌 (23)
참고문헌 신청
[학술지(정
Afruza R / 2014 / Renin gene polymorphisms in bangladeshi hypertensive population / J Genomics 2 : 45 ~ 53
Borensztein P / 1994 / cis-regulatory elements and trans-acting factors directing basal and cAMP-stimulated human renin gene expression in chorionic cells / Circ Res 74 : 76
Frossard PM / 1999 / Human renin gene BglI dimorphism associated with hypertension in two independent populations / Clin Genet 56 : 428 ~ 433
Fuchs S / 2002 / Functionality of two new polymorphisms in the human renin gene enhancer region / J Hypertens 20 : 2391 ~ 2398
Afruza R / 2014 / Renin gene polymorphisms in bangladeshi hypertensive population / J Genomics 2 : 45 ~ 53
Borensztein P / 1994 / cis-regulatory elements and trans-acting factors directing basal and cAMP-stimulated human renin gene expression in chorionic cells / Circ Res 74 : 76
Frossard PM / 1999 / Human renin gene BglI dimorphism associated with hypertension in two independent populations / Clin Genet 56 : 428 ~ 433
Fuchs S / 2002 / Functionality of two new polymorphisms in the human renin gene enhancer region / J Hypertens 20 : 2391 ~ 2398
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