지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 242 - 248 (7page)
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Purpose: Low grade inflammation is a well-known characteristic in obese subjects.
We investigated body weight changes and inflammatory markers after 12-week intervention trial. Materials and Methods: Twenty-six obese subjects were enrolled and 19 (13 men and 6 women) completed the study. Sibutramine is an FDA-approved drug for body weight control; therefore, we chose this drug as the standard treatment medication in this study. Patients were randomly allocated to receive an anti-inflammatory agent (Diacerein treatment group; n = 12) or placebo (n = 7) for 12 weeks. Anthropometry, body proportion by dual-energy X-ray absorptiometry,and metabolic parameters at the beginning and end of study were measured and compared. Results: The treatment group had a tendency towards more reduction in anthropometry as compared to the placebo group, in body weight reduction (- 7.0 kg vs. - 4.6 kg), body mass index (- 2.51 kg/m2 vs. - 1.59 kg/m^2), and waist circumference (- 7.3 cm vs. - 4.4 cm). These reductions were not statistically significant.
Changes in levels of high-sensitivity C-reactive protein and adiponectin in the treatment group were more favorable than in the placebo group. Conclusion: This small pilot study showed no statistical difference for changes in anthropometry,and inflammatory markers between the two groups. Therefore, we could not find any additional effects of Diacerein on weight loss and inflammatory variables in this study.
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참고문헌 (23)
참고문헌 신청
[학술지(정기간행물)] -
Bastard JP / 2006 / Recent advances in the relationship between obesity, inflammation, and insulin resistance / Eur Cytokine Netw 17 : 4 ~ 12
Caballero AE / 2004 / The differential effects of metformin on markers of endothelail activation and inflammation in subjects with impaired glucose tolerance: a placebo-cont
Chu NV / 2002 / Differential effects of metformin and troglitazone on cardiovascular risk factors in patients with type 2 diabetes / Diabetes Care 25 : 542 ~ 549
Cook DG / 2000 / C-reactive protein concentration in children: relationship to adiposity and other cardiovascular risk factors / Atherosclerosis 149 : 139 ~ 150
Bastard JP / 2006 / Recent advances in the relationship between obesity, inflammation, and insulin resistance / Eur Cytokine Netw 17 : 4 ~ 12
Caballero AE / 2004 / The differential effects of metformin on markers of endothelail activation and inflammation in subjects with impaired glucose tolerance: a placebo-cont
Chu NV / 2002 / Differential effects of metformin and troglitazone on cardiovascular risk factors in patients with type 2 diabetes / Diabetes Care 25 : 542 ~ 549
Cook DG / 2000 / C-reactive protein concentration in children: relationship to adiposity and other cardiovascular risk factors / Atherosclerosis 149 : 139 ~ 150
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