개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,408 - 1,414 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: Sedatives must be carefully titrated for patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) as oversedationmay lead to disastrous respiratory outcomes. This study aimed to investigate the relations between the effect-site concentration(Ce) of propofol and sedation and airway obstruction levels in patients with OSAHS.
Materials and Methods: In 25 patients with OSAHS, sedation was induced by 2% propofol using target-controlled infusion. Sedationand airway obstruction levels were assessed using the Observer’s Assessment of Alertness/Sedation Scale and a four-category scale, respectively. The relationships between propofol Ce and sedation and airway obstruction were evaluated using a sigmoid Emax model. Pharmacodynamic modeling incorporating covariates was performed using the Nonlinear Mixed Effects Modeling VII software.
Results: Increased propofol Ce correlated with the depth of sedation and the severity of airway obstruction. Predicted Ce50(m) (Ce associated with 50% probability of an effect≥m) for sedation scores (m≥2, 3, 4, and 5) and airway-obstruction scores (m≥2, 3, and 4) were 1.61, 1.78, 1.91, and 2.17 μg/mL and 1.53, 1.64, and 2.09 μg/mL, respectively. Including the apnea-hypopnea index (AHI) as a covariate in the analysis of Ce50(4) for airway obstruction significantly improved the performance of the basic model (p<0.05).
Conclusion: The probability of each sedation and airway obstruction score was properly described using a sigmoid Emax model with a narrow therapeutic range of propofol Ce in OSAHS patients. Patients with high AHI values need close monitoring to ensure that airway patency is maintained during propofol sedation.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Benumof JL / 2002 / Creation of observational unit may decrease sleep apnea risk / APSF Newsletter 17 : 39 ~
Chernik DA / 1990 / Validity and reliability of the Observer’s Assessment of Alertness/Sedation Scale: study with intravenous midazolam / J Clin Psychopharmacol 10 : 244 ~ 2
Chung F / 1982 / Sleep apnoea syndrome and anaesthesia / Can Anaesth Soc J 29 : 439 ~ 445
Collop NA / 2007 / Clinical guidelines for the use of unattended portable monitors in the diagnosis of obstructive sleep apnea in adult patients. Portable Monitoring Task Fo
Dhonneur G / 1999 / Postoperative obstructive apnea / Anesth Analg 89 : 762 ~ 767
Chernik DA / 1990 / Validity and reliability of the Observer’s Assessment of Alertness/Sedation Scale: study with intravenous midazolam / J Clin Psychopharmacol 10 : 244 ~ 2
Chung F / 1982 / Sleep apnoea syndrome and anaesthesia / Can Anaesth Soc J 29 : 439 ~ 445
Collop NA / 2007 / Clinical guidelines for the use of unattended portable monitors in the diagnosis of obstructive sleep apnea in adult patients. Portable Monitoring Task Fo
Dhonneur G / 1999 / Postoperative obstructive apnea / Anesth Analg 89 : 762 ~ 767
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
새로운 진정진료지침
대한치과의사협회지
2023 .03
-
Korean clinical practice guidelines for diagnostic and procedural sedation
Korean Journal of Anesthesiology
2024 .02
-
Considerable Variability of Procedural Sedation and Analgesia Practices for Gastrointestinal Endoscopic Procedures in Europe
Clinical Endoscopy
2016 .01
-
Characteristics of Obstructive Sleep Apnea Patients With a Low Body Mass Index: Emphasis on the Obstruction Site Determined by Drug-Induced Sleep Endoscopy
Clinical and Experimental Otorhinolaryngology
2020 .01
-
Dexmedetomidine intravenous sedation using a patient-controlled sedation infusion pump: a case report
Journal of dental anesthesia and pain medicine
2016 .01
-
2021 Korean Society of Gastrointestinal Endoscopy Clinical Practice Guidelines for Endoscopic Sedation
Gut and Liver
2022 .05
-
The Emerging Role of Drug-Induced Sleep Endoscopy in the Management of Obstructive Sleep Apnea
Clinical and Experimental Otorhinolaryngology
2021 .01
-
Safety of EEG BIS-guided nurse-administered procedural sedation during gastro-intestinal intervention
International Journal of Gastrointestinal Intervention
2024 .01
-
A Simulation Study of Propofol Effect-Site Concentration for Appropriate Sedation in Pediatric Patients Undergoing Brain MRI: Pharmacodynamic Analysis
Yonsei Medical Journal
2017 .01
-
Three Cases of Pierre Robin Sequence with Upper Airway Obstruction Relieved by Nasopharyngeal Airway Insertion
Neonatal medicine
2019 .01
-
Inhalation Sedation: A Systematic Review and Meta-Analysis
Journal of Acute Care Surgery
2019 .01
-
Deep Sedation in Traumatic Brain Injury Patients
Korean Journal of Neurotrauma
2023 .06
-
Performing High-resolution Impedance Manometry After Endoscopy With Conscious Sedation Has Negligible Effects on Esophageal Motility Results
Journal of Neurogastroenterology and Motility (JNM)
2020 .01
-
Considerations for submucosal midazolam administration in combination with oral and inhaled medications for sedation of pediatric dental patients
Journal of dental anesthesia and pain medicine
2015 .01
-
Room for Quality Improvement in Endoscopist-Directed Sedation: Results from the First Nationwide Survey in Korea
Gut and Liver
2016 .01
-
Tongue-lip adhesion in Pierre Robin sequence
대한구강악안면외과학회지
2016 .01
-
2021 Korean Society of Gastrointestinal Endoscopy Clinical Practice Guidelines for Endoscopic Sedation
Clinical Endoscopy
2022 .03
-
Impact of Moderate versus Deep Sedation and Trainee Participation on Adenoma Detection Rate - Analysis of a Veteran Population
Clinical Endoscopy
2021 .01
-
Cone-beam CT analysis of patients with obstructive sleep apnea compared to normal controls
Imaging science in dentistry
2016 .01
-
수련병원 내 소아치과 전공의 진정법 교육 현황 조사
대한소아치과학회지
2021 .08
이 논문의 저자 정보
최근 본 자료
댓글(0)
0