지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 1,624 - 1,630 (7page)
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초록· 키워드
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Purpose: Mentally disabled patients show different recovery profiles compared to normal patients after general anesthesia. However, the relationship of dose-recovery profiles of mentally disabled patients has never been compared to that of normal patients. Materials and Methods: Twenty patients (10 mentally disabled patients and 10 mentally intact patients) scheduled to dental surgery under general anesthesia was recruited. Sevoflurane was administered to maintain anesthesia during dental treatment. At the end of the surgery, sevoflurane was discontinued. End-tidal sevoflurane and recovery of consciousness (ROC) were recorded after sevoflurane discontinuation. The pharmacodynamic relation between the probability of ROC and end-tidal sevoflurane concentration was analyzed using NONMEM software (version VII). Results: End-tidal sevoflurane concentration associated with 50% probability of ROC (C50) and γ value were lower in the mentally disabled patients (C50=0.37 vol %, γ=16.5 in mentally intact patients, C50=0.19 vol %, γ=4.58 in mentally disabled patients). Mentality was a significant covariate of C50 for ROC and γ value to pharmacodynamicmodel. Conclusion: A sigmoid Emanx model explains the pharmacodynamicrelationship between end-tidal sevoflurane concentration and ROC. Mentally disabled patients may recover slower from anesthesia at lower sevoflurane concentrationat ROC an compared to normal patients.
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참고문헌 (19)
참고문헌 신청
/ 2000 / Reliability of pharmacodynamic analysis by logistic regression: a computer simulation study / Anesthesiology 92 : 985 ~ 992
Cechova S / 2006 / Inhibition of glutamate transporters increases the minimum alveolar concentration for isoflurane in rats / Br J Anaesth 97 : 192 ~ 195
Chernik DA / 1990 / Validity and reliability of the Observer’s Assessment of Alertness/Sedation Scale: study with intravenous midazolam / J Clin Psychopharmacol 10 : 244 ~ 2
Escribano-Hernandez A / 2012 / Evaluation of satisfaction among relatives of mentally disabled patients who were users of a dental care protocol under general anaesthesia / M
Hung WT / 2003 / Anesthetic management of dental procedures in mentally handicapped patients / Acta Anaesthesiol Sin 41 : 65 ~ 70
Cechova S / 2006 / Inhibition of glutamate transporters increases the minimum alveolar concentration for isoflurane in rats / Br J Anaesth 97 : 192 ~ 195
Chernik DA / 1990 / Validity and reliability of the Observer’s Assessment of Alertness/Sedation Scale: study with intravenous midazolam / J Clin Psychopharmacol 10 : 244 ~ 2
Escribano-Hernandez A / 2012 / Evaluation of satisfaction among relatives of mentally disabled patients who were users of a dental care protocol under general anaesthesia / M
Hung WT / 2003 / Anesthetic management of dental procedures in mentally handicapped patients / Acta Anaesthesiol Sin 41 : 65 ~ 70
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