지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 800 - 806 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: This analysis was done to investigate the optimal regimen for fentanyl-based intravenous patient-controlled analgesia (IV-PCA) by finding a safe and effectivebackground infusion rate and assessing the effect of adding adjuvant drugs to the PCA regimen. Materials and Methods: Background infusion rate of fentanyl,type of adjuvant analgesic and/or antiemetic that was added to the IV-PCA, and patients that required rescue analgesics and/or antiemetics were retrospectivelyreviewed in 1827 patients who underwent laparoscopic abdominal surgery at a single tertiary hospital. Results: Upon multivariate analysis, lower background infusionrates, younger age, and IV-PCA without adjuvant analgesics were identified as independent risk factors of rescue analgesic administration. Higher background infusion rates, female gender, and IV-PCA without additional 5HT3 receptor blockers were identified as risk factors of rescue antiemetics administration. A background infusion rate of 0.38 μg/kg/hr [area under the curve (AUC) 0.638] or lower required rescue analgesics in general, whereas, addition of adjuvant analgesicsdecreased the rate to 0.37 μg/kg/hr (AUC 0.712) or lower. A background infusionrate of 0.36 μg/kg/hr (AUC 0.638) or higher was found to require rescue antiemeticsin general, whereas, mixing antiemetics with IV-PCA increased the rate to 0.37 μg/kg/hr (AUC 0.651) or higher. Conclusion: Background infusion rates of fentanyl between 0.12 and 0.67 μg/kg/hr may safely be used without any serious side effects for IV-PCA. In order to approach the most reasonable background infusionrate for effective analgesia without increasing postoperative nausea and vomiting, adding an adjuvant analgesic and an antiemetic should always be considered.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Ballantyne JC / 1993 / Postoperative patient-controlled analgesia: meta-analyses of initial randomized control trials / J Clin Anesth 5 : 182 ~ 193
Cepeda MS / 2003 / Side effects of opioids during short-term administration: effect of age, gender, and race / Clin Pharmacol Ther 74 : 102 ~ 112
Fleming BM / 1992 / A survey of complications documented in a quality-control analysis of patient-controlled analgesia in the postoperative patient / J Pain Symptom Manage 7
Grass JA / 2005 / Patient-controlled analgesia / Anesth Analg 101 (5 Suppl) : S44 ~ S61
Guler T / 2004 / A background infusion of morphine enhances patient-controlled analgesia after cardiac surgery / Can J Anaesth 51 : 718 ~ 722
Cepeda MS / 2003 / Side effects of opioids during short-term administration: effect of age, gender, and race / Clin Pharmacol Ther 74 : 102 ~ 112
Fleming BM / 1992 / A survey of complications documented in a quality-control analysis of patient-controlled analgesia in the postoperative patient / J Pain Symptom Manage 7
Grass JA / 2005 / Patient-controlled analgesia / Anesth Analg 101 (5 Suppl) : S44 ~ S61
Guler T / 2004 / A background infusion of morphine enhances patient-controlled analgesia after cardiac surgery / Can J Anaesth 51 : 718 ~ 722
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