지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 709 - 714 (6page)
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Purpose: The elucidation of thalamocortical connections between the mediodorsal nucleus (MD) of thalamus and the prefrontal cortex (PFC) is important in the clinicalfields of neurorehabilitation and psychiatry. However, little is known about these connections in human brain. We attempted to identify and investigate the anatomicalcharacteristics of the thalamocortical connection between MD and PFC in human brain using diffusion tensor tractography (DTT). Materials and Methods:Thirty-two healthy volunteers were recruited for this study. Diffusion tensor images were scanned using a 1.5-T. A seed region of interest was placed at the MD of the thalamus on coronal images, and target regions of interest were placed on the dorsolateral prefrontal cortex (DLPFC), the ventrolateral prefrontal cortex (VLPFC), and the orbitofrontal cortex (OFC), respectively. The three thalamocorticalconnections found were reconstructed using Functional Magnetic Resonance Imaging of the Brain (FMRIB) software. Results: The three thalamocortical connectionswere arranged in subcortical white matter in the following order from upperto lower levels: the DLPFC, the VLPFC, and the OFC. In terms of fractional anisotropy and mean diffusivity values, no significant differences were observed between the DLPFC, VLPFC and OFC (p>0.05). In contrast, the OFC tract volumewas higher than those of the DLPFC and the VLPFC (p<0.05). Conclusion: Three thalamocortical connections were reconstructed between MD and PFCs in human brain using DTT. We believe that the results of this study would be helpful to clinicians in treating frontal network syndrome and psychiatric diseases.
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참고문헌 (30)
참고문헌 신청
Johansen-Berg H / 2005 / Functional-anatomical validation and individual variation of diffusion tractography-based segmentation of the human thalamus / Cereb Cortex 15:31~39
Petrides M / 2005 / Lateral prefrontal cortex: architectonic and functional organization / Philos Trans R Soc Lond B Biol Sci 360:781~795
Kringelbach ML / 2005 / The human orbitofrontal cortex: linking reward to hedonic experience / Nat Rev Neurosci 6:691~702
Kubota M / 2013 / Thalamocortical disconnection in the orbitofrontal region associated with cortical thinning in schizophrenia / JAMA Psychiatry 70:12~21
Barbas H / 1991 / Diverse thalamic projections to the prefrontal cortex in the rhesus monkey / J Comp Neurol 313 : 65 ~ 94
Petrides M / 2005 / Lateral prefrontal cortex: architectonic and functional organization / Philos Trans R Soc Lond B Biol Sci 360:781~795
Kringelbach ML / 2005 / The human orbitofrontal cortex: linking reward to hedonic experience / Nat Rev Neurosci 6:691~702
Kubota M / 2013 / Thalamocortical disconnection in the orbitofrontal region associated with cortical thinning in schizophrenia / JAMA Psychiatry 70:12~21
Barbas H / 1991 / Diverse thalamic projections to the prefrontal cortex in the rhesus monkey / J Comp Neurol 313 : 65 ~ 94
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