지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 635 - 643 (9page)
이용수
초록· 키워드
오류제보하기
Purpose: Peak oxygen uptake (peak VO2) and ventilatory inefficiency (VE/VCO2 slope) have proven to be strong prognostic markers in patients with chronic heart failure (CHF). Recently increased red cell distribution width (RDW) has emerged as an additional predictor of poor outcome in CHF. We sought to evaluate the relationshipbetween RDW and cardiopulmonary exercise test (CPET) parameters in CHF patients and healthy controls. Materials and Methods: 85 ambulatory CHF patients (68 men, 54±10 years) and 107 healthy controls, who underwent a symptom-limited CPET on a treadmill according to the modified Bruce ramp protocol, were enrolled. CHF patients and healthy controls were divided into RDW tertile groups and laboratory, echocardiographic, and CPET results were analyzed. Results:For patients with CHF, compared with patients in the lowest RDW tertile, those in the highest tertile had lower peak VO2 (22 mL/kg/min vs. 28 mL/kg/min, p<0.001) and higher VE/VCO2 slope (31 vs. 25, p=0.004). Multivariate regression analysis revealed RDW to be an independent predictor for peak VO2 (β=-0.247, p=0.035) and VE/VCO2 slope (β=0.366, p=0.004). The optimal cutoff value of RDW for predicting peak VO2 ≤20 mL/kg/min and VE/VCO2 slope ≥34 was 13.6% (sensitivity 53%, specificity 89%) and 13.4% (sensitivity 75%, specificity 82%), respectively. In contrast, for healthy controls, RDW was not related to both peak VO2 and VE/VCO2 slope. Conclusion: Higher RDW is independently relatedto peak VO2 and VE/VCO2 slope only in patients with CHF. RDW assessment, an inexpensive and simple method, might help predict functional capacity and ventilatory efficiency in these patients.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Al-Najjar Y / 2009 / Red cell distribution width: an inexpensive and powerful prognostic marker in heart failure / Eur J Heart Fail 11 : 1155 ~ 1162
Allen LA / 2010 / Validation and potential mechanisms of red cell distribution width as a prognostic marker in heart failure / J Card Fail 16 : 230 ~ 238
Appleton CP / 1988 / Relation of transmitral flow velocity patterns to left ventricular diastolic function: new insights from a combined hemodynamic and Doppler echocardiogr
Chiari MM / 1995 / Influence of acute inflammation on iron and nutritional status indexes in older inpatients / J Am Geriatr Soc 43 : 767 ~ 771
Chua TP / 1997 / Clinical correlates and prognostic significance of the ventilatory response to exercise in chronic heart failure / J Am Coll Cardiol 29 : 1585 ~ 1590
Allen LA / 2010 / Validation and potential mechanisms of red cell distribution width as a prognostic marker in heart failure / J Card Fail 16 : 230 ~ 238
Appleton CP / 1988 / Relation of transmitral flow velocity patterns to left ventricular diastolic function: new insights from a combined hemodynamic and Doppler echocardiogr
Chiari MM / 1995 / Influence of acute inflammation on iron and nutritional status indexes in older inpatients / J Am Geriatr Soc 43 : 767 ~ 771
Chua TP / 1997 / Clinical correlates and prognostic significance of the ventilatory response to exercise in chronic heart failure / J Am Coll Cardiol 29 : 1585 ~ 1590
이 논문의 저자 정보
최근 본 자료
댓글(0)
0