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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 387 - 394 (8page)
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Purpose: Gastrointestinal integrity and immune surveillance are affected by stress. Stress also adversely affects mucosal barrier function. β-defensins constitute an integralcomponent of the innate immune system as antimicrobial peptides, serving as the first line of defense against microbial pathogens at the epithelial surfaces of the upper digestive mucosa. The primary objective of this study was to determine the effects of stress on the expression profile of mouse β-defensin-3 in the upper digestivemucosa of mice with diabetes. Materials and Methods: We established a mouse model of restraint stress by using NSY/Hos mice with type 2 diabetes mellitus. We used real-time polymerase chain reaction, in situ hybridization, and immunohistochemistryto investigate the effects of stress and glucocorticoid administrationon mouse β-defensin-3 expression in the upper digestive mucosa of the gingiva, esophagus, and stomach. Results: Mouse β-defensin-3 mRNA expression was higher in the esophagus than in the gingiva or stomach (p<0.05). In the esophagus, mouse β-defensin-3 mRNA expression was lower in stressed mice than in non-stressed mice (p<0.05). Furthermore, immunoreactivity to mouse β-defensin-3 proteinwas lower in the esophagus of stressed mice than non-stressed mice, consistent with the results of mRNA expression analysis. Systemic glucocorticoid administrationalso downregulated esophageal mouse β-defensin-3 mRNA expression. Conclusion:Our novel findings show that stress decreases mouse β-defensin-3 expressionin the esophagus of mice with diabetes, possibly due to increased endogenous glucocorticoid production. It appears to be highly likely that stress management may normalize mucosal antimicrobial defenses in patients with diabetes.
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참고문헌 (41)
참고문헌 신청
Meddings JB / 2000 / Environmental stress-induced gastrointestinal permeability is mediated by endogenous glucocorticoids in the rat / Gastroenterology 119:1019~1028
Mawdsley JE / 2005 / Psychological stress in IBD: new insights into pathogenic and therapeutic implications / Gut 54:1481~1491
Glaser R / 2005 / Stress-associated immune dysregulation and its importance for human health: a personal history of psychoneuroimmunology / Brain Behav Immun 19:3~11
Marucha PT / 1998 / Mucosal wound healing is impaired by examination stress / Psychosom Med 60:362~365
Ebrecht M / 2004 / Perceived stress and cortisol levels predict speed of wound healing in healthy male adults / Psychoneuroendocrinology 29:798~809
Mawdsley JE / 2005 / Psychological stress in IBD: new insights into pathogenic and therapeutic implications / Gut 54:1481~1491
Glaser R / 2005 / Stress-associated immune dysregulation and its importance for human health: a personal history of psychoneuroimmunology / Brain Behav Immun 19:3~11
Marucha PT / 1998 / Mucosal wound healing is impaired by examination stress / Psychosom Med 60:362~365
Ebrecht M / 2004 / Perceived stress and cortisol levels predict speed of wound healing in healthy male adults / Psychoneuroendocrinology 29:798~809
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