지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 442 - 448 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: Anti-tumor necrosis factor-alpha (TNF-α) medications represent a major advancement in the management of chronic inflammatory diseases. However, these agents are associated with increased risks of tuberculosis (TB) and other seriousinfections. The aim of this study was to evaluate the incidences of such disease among tertiary hospitals in Korea. Materials and Methods: We retrospectively studied patients who received anti-TNF-α therapy; we reviewed serious infections including TB that developed within 6 months after initiation of anti-TNF-α therapy. Data concerning patient demographics, types of anti-TNF-α agents, concomitantimmunosuppressive drugs use, and infection details were collected. Results: A total 175 patients treated with infliximab (n=72) or adalimumab (n=103) with the following conditions were enrolled: Crohn’s disease, 34 (19.4%); ulcerative colitis, 20 (11.4%); ankylosing spondylitis, 82 (46.9%); and rheumatoid arthritis, 39 (22.2%). There were 18 cases (6.0%) of serious infections. The most common site of serious infection was the intra-abdomen (n=6), followed by TB (n=3), skin and soft tissue (n=3), bone and joints (n=2), ocular neurons (n=2), lower respiratorytract (n=1), and urinary tract (n=1). Of the 175 patients, only 3 cases showed development of TB. Furthermore, of all those who developed TB, none had taken anti-TB chemoprophylaxis prior to treatment with an anti-TNF agent due to negativescreening results. Conclusion: Serious infections with anti-TNF-α therapy were uncommon among tertiary hospitals in Korea; TB was the second most frequentinfection. Nevertheless, there were no TB reactivations after anti-TB chemoprophylaxis. Accordingly, physicians should be aware of TB in subjects undergoinganti-TNF-α therapy, especially in countries with a high prevalence of TB.
목차
등록된 정보가 없습니다.
참고문헌 (37)
참고문헌 신청
박재석 / 2012 / 결핵의 치료지침 / 대한내과학회지 82(3):269~273
Im JG / 1993 / Pulmonary tuberculosis: CT findings--early active disease and sequential change with antituberculous therapy / Radiology 186:653~660
Malaviya AN / 2009 / Preventing tuberculosis flare in patients with inflammatory rheumatic diseases receiving tumor necrosis factor-alpha inhibitors in India -- An audit report / J Rheumatol 36:1414~1420
Korean National Tuberculosis Association / Trend of case notification rate per 100,000 by year, 2004-2011
Hong SJ / 2012 / Factors leading to under-reporting of tuberculosis in the private sector in Korea / INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 16(9):1221~1227
Im JG / 1993 / Pulmonary tuberculosis: CT findings--early active disease and sequential change with antituberculous therapy / Radiology 186:653~660
Malaviya AN / 2009 / Preventing tuberculosis flare in patients with inflammatory rheumatic diseases receiving tumor necrosis factor-alpha inhibitors in India -- An audit report / J Rheumatol 36:1414~1420
Korean National Tuberculosis Association / Trend of case notification rate per 100,000 by year, 2004-2011
Hong SJ / 2012 / Factors leading to under-reporting of tuberculosis in the private sector in Korea / INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 16(9):1221~1227
이 논문의 저자 정보
최근 본 자료
댓글(0)
0