지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 469 - 474 (6page)
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초록· 키워드
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Purpose: We tried to evaluate the difference in the expression of carbonic anhydrase (CA) III and heat shock protein (Hsp) 70 betweenlaryngopharyngeal reflux disease (LPRD) and non-LPRD patients.
Materials and Methods: The study involved 28 patients who underwent laryngeal microsurgery due to benign laryngeal disease from March to August 2008. Reflux symptom index (RSI) and reflux finding score (RFS) were measured for each person, and they were assigned either to the LPRD group (n=10) or non-LPRD group (n=18). Tissue samples were obtained from the mucosa of posteriorcommissure, and immunohistochemistry (IHC) staining of CAIII and Hsp70 was performed. The IHC scores were measuredand compared with clinical features including RSI and RFS.
Results: Total 10 patients were assigned as LPRD group, and 18 patients were as control group. The mean IHC score of CAIII and Hsp70 was 1.70±1.06 and 1.90±0.88, respectively, in LPRD patients, whereas the mean IHC score of CAIII and Hsp70 was 0.78±0.73 and 0.94±0.87, respectively, in non-LPRD patients. The difference between two groups was statistically significant (p<0.05).
Conclusion: CAIII and Hsp70 expressions were higher in LPRD patients that in non-LPRD patients, suggesting the possibility as one of biomomarker in LPRD diagnosis.
목차
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참고문헌 (21)
참고문헌 신청
Hopwood D / 1997 / Oesophageal damage and defence in reflux oesophagitis: pathophysiological and cell biological mechanisms / Prog Histochem Cytochem 32:1~42
Mesallam TA / 2007 / Reflux symptom index versus reflux finding score / Ann Otol Rhinol Laryngol 116:436~440
Koufman JA / 1991 / The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury / Laryngoscope 101(4 Pt 2 Suppl 53):1~78
Ward PH / 1988 / Reflux as an etiological factor of carcinoma of the laryngopharynx / Laryngoscope 98:1195~1199
Woo P / 1996 / Association of esophageal reflux and globus symptom: comparison of laryngoscopy and 24-hour pH manometry / Otolaryngol Head Neck Surg 115:502~507
Mesallam TA / 2007 / Reflux symptom index versus reflux finding score / Ann Otol Rhinol Laryngol 116:436~440
Koufman JA / 1991 / The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury / Laryngoscope 101(4 Pt 2 Suppl 53):1~78
Ward PH / 1988 / Reflux as an etiological factor of carcinoma of the laryngopharynx / Laryngoscope 98:1195~1199
Woo P / 1996 / Association of esophageal reflux and globus symptom: comparison of laryngoscopy and 24-hour pH manometry / Otolaryngol Head Neck Surg 115:502~507
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