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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,150 - 1,154 (5page)
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NADPH oxidase produces a large amount of reactive oxygen species (ROS) in Helicobacterpylori (H. pylori)-induced gastric epithelial cells. Even though ROS mediateapoptotic cell death, direct involvement of NADPH oxidase on H. pylori-inducedapoptosis remains unclear. Besides, H. pylori isolates show a high degree of genetic variability. The predominant genotype of H. pylori in Korea has been reportedas cagA+, vacA s1b, m2, iceA genotype. Present study aims to investigate whether NADPH oxidase-generated ROS mediate apoptosis in human gastric epithelialAGS cells infected with H. pylori in a Korean isolate. AGS cells were pretreatedwith or without an NADPH oxidase inhibitor diphenyleneiodonium (DPI) and cultured in the presence of H. pylori at a bacterium/cell ratio of 300:1. Cell viability,hydrogen peroxide level, DNA fragmentation, and protein levels of p53, Bcl-2, and Bax were determined. Results showed that H. pylori inhibited cell viability with the density of H. pylori added to the cells. Inhibition of NADPH oxidase by DPI suppressed H. pylori-induced cell death, increased hydrogen peroxide, DNA fragmentation, and the ratio of Bax/Bcl-2, and p53 induction in AGS cells dose-dependently.
The results suggest that targeting NADPH oxidase may prevent the developmentof gastric inflammation associated with H. pylori infection by suppressingabnormal apoptotic cell death of gastric epithelial cells.
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참고문헌 (21)
참고문헌 신청
Arslan D / 2007 / Is there an oxidative stress in children with Helicobacter pylori infection? / Saudi Med J 28 : 1222 ~ 1226
Bagchi D / 1996 / Production of reactive oxygen species by gastric cells in association with Helicobacter pylori / Free Radic Res 24 : 439 ~ 450
Bauer G / 2014 / Helicobacter pylori protects oncogenically transformed cells from reactive oxygen species-mediated intercellular induction of apoptosis / Carcinogenesis 35
Cha B / 2010 / HSP90beta interacts with Rac1 to activate NADPH oxidase in Helicobacter pylori-infected gastric epithelial cells / Int J Biochem Cell Biol 42 : 1455 ~ 1461
Cho SO / 2006 / Signaling for integrin alpha5/beta1 expression in Helicobacter pylori-infected gastric epithelial AGS cells / Ann N Y Acad Sci 1090 : 298 ~ 304
Bagchi D / 1996 / Production of reactive oxygen species by gastric cells in association with Helicobacter pylori / Free Radic Res 24 : 439 ~ 450
Bauer G / 2014 / Helicobacter pylori protects oncogenically transformed cells from reactive oxygen species-mediated intercellular induction of apoptosis / Carcinogenesis 35
Cha B / 2010 / HSP90beta interacts with Rac1 to activate NADPH oxidase in Helicobacter pylori-infected gastric epithelial cells / Int J Biochem Cell Biol 42 : 1455 ~ 1461
Cho SO / 2006 / Signaling for integrin alpha5/beta1 expression in Helicobacter pylori-infected gastric epithelial AGS cells / Ann N Y Acad Sci 1090 : 298 ~ 304
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