지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 861 - 870 (10page)
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Purpose: Both insulin and insulin-like growth factor (IGF)-1 signaling are key regulators of energy metabolism, cellular growth, proliferation, and survival. The IGF-1 receptor (IGF-1R) is overexpressed in most types of human cancers includingrenal cell carcinoma (RCC) with poor prognosis. Insulin receptor (IR) shares downstream effectors with IGF-1R; however, the expression and function of IR in the tumorigenesis of renal cancer remains elusive. Therefore, we examined the expressionof IR and its prognostic significance in clear cell RCC (CCRCC). Materialsand Methods: Immunohistochemical staining for IR was performed on 126 formalin-fixed paraffin-embedded CCRCC tissue samples. Eight of these cases were utilized for western blot analysis. The results were compared with various clinico-pathologic parameters of CCRCC and patient survival. Results: IR was expressed in the nuclei of CCRCC tumor cells in 109 cases (87.9%). Higher IR expression was significantly correlated with the presence of cystic change, lower Fuhrman nuclear grade, lower pathologic T stage, and lower TNM stage, although it wasn’t significantly related to diabetes status and patient survival. Western blot analyses supported the results of the immunohistochemistry studies. Conclusion: IR expression in CCRCC may be associated with favorable prognostic factors.
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참고문헌 (26)
참고문헌 신청
Allred DC / 1998 / Prognostic and predictive factors in breast cancer by immunohistochemical analysis / Mod Pathol 11
Baxter RC / 2000 / Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities / Am J Physiol Endocrinol Metab 278 : E967 ~ E976
Beauchamp MC / 2010 / Targeting insulin and insulin-like growth factor pathways in epithelial ovarian cancer / J Oncol 2010 : 257058 ~
Belfiore A / 2008 / IGF and insulin receptor signaling in breast cancer / J Mammary Gland Biol Neoplasia 13 : 381 ~ 406
Berry MG / 1948 / Marked insulin resistance in diabetes mellitus / Am J Med 4 : 923 ~ 926
Baxter RC / 2000 / Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities / Am J Physiol Endocrinol Metab 278 : E967 ~ E976
Beauchamp MC / 2010 / Targeting insulin and insulin-like growth factor pathways in epithelial ovarian cancer / J Oncol 2010 : 257058 ~
Belfiore A / 2008 / IGF and insulin receptor signaling in breast cancer / J Mammary Gland Biol Neoplasia 13 : 381 ~ 406
Berry MG / 1948 / Marked insulin resistance in diabetes mellitus / Am J Med 4 : 923 ~ 926
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