지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 980 - 986 (7page)
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Purpose: In clinical practice, some patients with asthma show incompletely reversibleairflow obstruction, resembling chronic obstructive pulmonary disease (COPD). The aim of this study was to analyze this overlap phenotype of asthma with COPD feature. Materials and Methods: A total of 256 patients, over the age of 40 years or more with a diagnosis of asthma, based on either 1) positive responseto bronchodilator: >200 mL forced expiratory volume in 1 s (FEV1) and >12% baseline or 2) positive methacholine or mannitol provocation test, were enrolled. Among the asthma patients, we defined the overlap group with incompletelyreversible airflow obstruction [postbronchodilator FEV1/forced vital capacity (FVC) <70] at the initial time of admission and continuing airflow obstruction afterat least 3 months follow up. We evaluated clinical features, serum eosinophil counts, serum total immunoglobulin (Ig) E with allergy skin prick test, spirometry, methacholine or mannitol provocation challenges and bronchodilator responses, based on their retrospective medical record data. All of the tests mentioned above were performed within one week. Results: The study population was divided into two groups: asthma only (62%, n=159, postbronchodilator FEV1/FVC ≥70) and overlap group (38%, n=97, postbronchodilator FEV1/FVC <70). The overlap group was older, and contained more males and a higher percentage of current or ex-smokers than the asthma only group. Significantly lower FEV1 and higher total lung capacity, functional residual capacity, and residual volume were observed in the overlap group. Finally, significantly lower serum eosinophil count and higher IgE were seen in the overlap group. Conclusion: Our results showed that the overlapphenotype was older, male asthmatic patients who have a higher lifetime smoking intensity, more atopy and generally worse lung function.
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참고문헌 (25)
참고문헌 신청
Anderson SD / 2009 / Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma / Respir Res 10 : 4 ~
Bernstein IL / 2008 / Allergy diagnostic testing: an updated practice parameter / Ann Allergy Asthma Immunol 100 (3 Suppl 3) : S1 ~ S148
Brannan JD / 2005 / The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: a phase 3 comparison study with hy
Crapo RO / 2000 / Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of D
Enright PL / 2002 / The diagnosis and management of asthma is much tougher in older patients / Curr Opin Allergy Clin Immunol 2 : 175 ~ 181
Bernstein IL / 2008 / Allergy diagnostic testing: an updated practice parameter / Ann Allergy Asthma Immunol 100 (3 Suppl 3) : S1 ~ S148
Brannan JD / 2005 / The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: a phase 3 comparison study with hy
Crapo RO / 2000 / Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of D
Enright PL / 2002 / The diagnosis and management of asthma is much tougher in older patients / Curr Opin Allergy Clin Immunol 2 : 175 ~ 181
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