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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 987 - 993 (7page)
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Purpose: Fluoroquinolones, rapidly gaining prominence in treatment of Stenotrophomonasmaltophilia (SMP), are noted for their potency and tolerability. However, SMP may rapidly acquire resistance to fluoroquinolones. We evaluated associations of clinical factors with acquisition of levofloxacin resistance (LFr) in SMP. Materialsand Methods: Our retrospective cohort study was based on patient data collectedbetween January 2008 and June 2010. Through screening of 1275 patients, we identified 122 patients with data for SMP antibiotic susceptibility testing in ≥3 serial SMP isolates. Results: We assigned the 122 patients to either the SS group (n=54) in which levofloxacin susceptibility was maintained or the SR group (n=31) in which susceptible SMP acquired resistance. In multivariate regression analysis, exposure to levofloxacin for more than 3 weeks [odds ratio (OR) 15.39, 95% confidential interval(CI) 3.08--76.93, p=0.001] and co-infection or co-colonization with Klebsiella pneumoniae resistant to levofloxacin (OR 4.85, 95% CI 1.16--20.24, p=0.030) were independently associated with LFr acquisition in SMP. Conclusion: Acquisition of LFr during serial sampling of SMP was related to the levofloxacin exposure.
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참고문헌 (21)
참고문헌 신청
Abbott IJ / 2011 / Stenotrophomonas maltophilia: emerging disease patterns and challenges for treatment / Expert Rev Anti Infect Ther 9 : 471 ~ 488
Araoka H / 2012 / Rapidly progressive fatal hemorrhagic pneumonia caused by Stenotrophomonas maltophilia in hematologic malignancy / Transpl Infect Dis 14 : 355 ~ 363
Brooke JS / 2012 / Stenotrophomonas maltophilia: an emerging global opportunistic pathogen / Clin Microbiol Rev 25 : 2 ~ 41
CLSI / 2011 / Performance standards for antimicrobial susceptibility testing; twenty-first informational supplement / Clinical and Laboratory Standard Institute
Chang LL / 2007 / Increased incidence of class 1 integrons in trimethoprim/sulfamethoxazole-resistant clinical isolates of Stenotrophomonas maltophilia / J Antimicrob Chemoth
Araoka H / 2012 / Rapidly progressive fatal hemorrhagic pneumonia caused by Stenotrophomonas maltophilia in hematologic malignancy / Transpl Infect Dis 14 : 355 ~ 363
Brooke JS / 2012 / Stenotrophomonas maltophilia: an emerging global opportunistic pathogen / Clin Microbiol Rev 25 : 2 ~ 41
CLSI / 2011 / Performance standards for antimicrobial susceptibility testing; twenty-first informational supplement / Clinical and Laboratory Standard Institute
Chang LL / 2007 / Increased incidence of class 1 integrons in trimethoprim/sulfamethoxazole-resistant clinical isolates of Stenotrophomonas maltophilia / J Antimicrob Chemoth
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