지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 960 - 966 (7page)
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초록· 키워드
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Purpose: The serum levels of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) have recently been shown to be correlated highly with disease activity in patients with intestinal Behçet’s disease (BD). However, it remains unclearwhether sTREM-1 levels reflect endoscopic activity in intestinal BD. This study aimed to evaluate the correlation of sTREM-1 levels with endoscopic activityin intestinal BD. Materials and Methods: A total of 84 patients with intestinal BD were enrolled. Endoscopic activity was compared with sTREM-1 levels as well as other laboratory findings, including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). Results: sTREM-1 levels were significantly increasedin intestinal BD patients compared with controls (37.98±27.09 pg/mL vs. 16.65±7.76 pg/mL, p=0.002), however, there was no difference between endoscopicallyquiescent and active diseases (43.53±24.95 pg/mL vs. 42.22±32.68 pg/mL, p=0.819). Moreover, serum sTREM-1 levels did not differ in terms of number,shape, depth, size, margin, or type of ulcer in patients with intestinal BD. However, mean ESR and CRP levels in patients with active disease were significantlyhigher than those in patients with quiescent disease (p=0.001, p<0.001, respectively). In addition, endoscopic activity scores for intestinal BD were correlatedsignificantly with both CRP levels (γ=0.329) and ESR (γ=0.298), but not with sTREM-1 levels (γ=0.166). Conclusion: Unlike CRP levels and ESR, serum sTREM-1 levels were not correlated with endoscopic activity in patients with intestinalBD.
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참고문헌 (23)
참고문헌 신청
Allez M / 2010 / Role of endoscopy in predicting the disease course in inflammatory bowel disease / World J Gastroenterol 16 : 2626 ~ 2632
Bouchon A / 2000 / Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes / J Immunol 164 : 4991 ~ 4995
Cheon JH / 2009 / Development and validation of novel diagnostic criteria for intestinal Behcet’s disease in Korean patients with ileocolonic ulcers / Am J Gastroenterol 10
Cheon JH / 2011 / Development, validation, and responsiveness of a novel disease activity index for intestinal Behcet’s disease / Inflamm Bowel Dis 17 : 605 ~ 613
Choi CH / 2006 / Anti-Saccharomyces cerevisiae antibody in intestina
Bouchon A / 2000 / Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes / J Immunol 164 : 4991 ~ 4995
Cheon JH / 2009 / Development and validation of novel diagnostic criteria for intestinal Behcet’s disease in Korean patients with ileocolonic ulcers / Am J Gastroenterol 10
Cheon JH / 2011 / Development, validation, and responsiveness of a novel disease activity index for intestinal Behcet’s disease / Inflamm Bowel Dis 17 : 605 ~ 613
Choi CH / 2006 / Anti-Saccharomyces cerevisiae antibody in intestina
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