지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 863 - 865 (3page)
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초록· 키워드
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Eperisone and afloqualone act by relaxing both skeletal and vascular smooth muscles to improve circulation and suppress pain reflex. These drugs are typically prescribed with non-steroidal anti-inflammatory drugs (NSAIDs) as painkillers. However, there have been no reports on serious adverse reactions to oral muscle relaxants; and this is the first report to describe three allergic reactions caused by eperisone and afloqualone. All three patients had histories of allergic reactions after oral intake of multiple painkillers, including oral muscle relaxants and NSAIDs, for chronic muscle pain. An open-label oral challenge test was performed with each drug to confirm which drugs caused the systemic reactions. All patients experienced the same reactions within one hour after oral intake of eperisone or afloqualone. The severity of these reactions ranged from laryngeal edema to hypotension. To confirm that the systemic reaction was caused by eperisone or afloqualone, skin prick testing and intradermal skin tests were performed with eperisone or afloqualone extract in vivo, and basophil activity tests were performed after stimulation with these drugs in vitro. In one patient with laryngeal edema, the intradermal test with afloqualone extract had a positive result, and CD63 expression levels on basophils increased in a dose-dependent manner by stimulation with afloqualone. We report three allergic reactions caused by oral muscle relaxants that might be mediated by non-immunoglobulin E-mediated responses. Since oral muscle relaxants such as eperisone and afloqualone are commonly prescribed for chronic muscle pain and can induce severe allergic reactions, we should prescribe them carefully.
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참고문헌 (9)
참고문헌 신청
Choonhakarn C. / 2001 / Non-pigmenting fixed drug eruption: a new case due to eperisone hydrochloride / Br J Dermatol 144 : 1288 ~ 1289
Demitsu T / 1998 / Fixed drug eruption due to afloqualone: the first reported case / J Dermatol 25 : 136 ~
Inoue S / 1989 / Mechanisms of action of eperisone on isolated dog saphenous arteries and veins / Jpn J Pharmacol 50 : 271 ~ 282
Iwase S / 1992 / Effect of a centrally-acting muscle relaxant, eperisone hydrochloride, on muscle sympathetic nerve activity in humans / Funct Neurol 7 : 459 ~ 470
Matsunaga M / 1997 / Long-lasting muscle relaxant activity of eperisone hydrochloride after percutaneous administration in rats / Jpn J Pharmacol 73 : 215 ~ 220
Demitsu T / 1998 / Fixed drug eruption due to afloqualone: the first reported case / J Dermatol 25 : 136 ~
Inoue S / 1989 / Mechanisms of action of eperisone on isolated dog saphenous arteries and veins / Jpn J Pharmacol 50 : 271 ~ 282
Iwase S / 1992 / Effect of a centrally-acting muscle relaxant, eperisone hydrochloride, on muscle sympathetic nerve activity in humans / Funct Neurol 7 : 459 ~ 470
Matsunaga M / 1997 / Long-lasting muscle relaxant activity of eperisone hydrochloride after percutaneous administration in rats / Jpn J Pharmacol 73 : 215 ~ 220
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