지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 748 - 752 (5page)
이용수
초록· 키워드
오류제보하기
Purpose: Many pediatric urologists still favor using prophylactic antibiotics to treat children with vesicoureteral reflux (VUR). However, breakthrough infection sometimes occurs,leading to significant increases in morbidity as a result of renal scarring. Therefore, we tested whether abnormal renal scan and other factors are predictive of breakthrough infection using univariate analyses. Materials and Methods: We retrospectively reviewed the medical records of 163 consecutive children who were diagnosed with vesicoureteral reflux between November 1997 and June 2010. Clinical parameters for the statistical analysis included form of presentation, gender, age, VUR grade, laterality, presence of intrarenal reflux, class of antibiotic drug, and presence of abnormal renal scan by Dimercapto-succinic acid. Clinical parameters used for prognostic factors were established by univariate analyses. Fisher’s exact test and unpaired t-test were done using SPSS software [SPSS ver. 12.0 (SPSS Inc., Chicago, IL, USA)]. Results: Breakthrough infection developed in 61 children (48.0%). A total of 58 children (45.7%) had abnormal renal scans. Time to development of breakthrough infection was significantly longer in girls (9.0±8.2 months) than in boys (5.8±4.8 months, p<0.05). On univariate analysis, though statistically not significant, the most predictive factor of breakthrough infection was abnormal renal scan (p=0.062). In patients with abnormal renal scans, breakthrough infection was not associated with mode of presentation, gender, grade or prophylactic antibiotics. However, there was a significant difference between patients younger than 1 year and those 1 year old or older. Mean±SD age at diagnosis of VUR in patients with breakthrough infection (1.14±3.14) was significantly younger than in those without breakthrough infection (5.05±3.31, p=0.009). There was also a significant difference between patients with bilateral or unilateral reflux (p=0.028). Conclusion: Our data showed that abnormal renal scan was the most predictive factor of breakthrough infection and demonstrated statistical significance in patients under the age of 1 year. Parents and physicians should remain aware that these patients are at high risk of breakthrough urinary tract infection, which may potentially lead to renal damage.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Agras K / 2007 / Resolution of cortical lesions on serial renal scans in children with acute pyelonephritis / Pediatr Radiol 37 : 153 ~ 158
Caione P / 2004 / Predictive risk factors for chronic renal failure in primary high-grade vesico-ureteric reflux / BJU Int 93 : 1309 ~ 1312
Elder JS / 1997 / Pediatric Vesicoureteral Reflux Guidelines Panel summary report on the management of primary vesicoureteral reflux in children / J Urol 157 : 1846 ~ 1851
Garin EH / 2006 / Clinical significance of primary vesicoureteral reflux and urinary antibiotic prophylaxis after acute pyelonephritis: a multicenter, randomized, controlled
Kanematsu A / 2005 / Renal scarring is associated with nonsecretion of blood type antigen in children with primary vesicoureteral reflux / J Urol 174 (4 Pt 2) : 1594 ~ 1597
Caione P / 2004 / Predictive risk factors for chronic renal failure in primary high-grade vesico-ureteric reflux / BJU Int 93 : 1309 ~ 1312
Elder JS / 1997 / Pediatric Vesicoureteral Reflux Guidelines Panel summary report on the management of primary vesicoureteral reflux in children / J Urol 157 : 1846 ~ 1851
Garin EH / 2006 / Clinical significance of primary vesicoureteral reflux and urinary antibiotic prophylaxis after acute pyelonephritis: a multicenter, randomized, controlled
Kanematsu A / 2005 / Renal scarring is associated with nonsecretion of blood type antigen in children with primary vesicoureteral reflux / J Urol 174 (4 Pt 2) : 1594 ~ 1597
이 논문의 저자 정보
최근 본 자료
댓글(0)
0