지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 258 - 261 (4page)
이용수
초록· 키워드
오류제보하기
Increased arterial stiffness is an independent predictor of cardiovascular disease independent from blood pressure. Recent studies have shed new light on the importance of inflammation on the pathogenesis of arterial stiffness. Arterial stiffness is associated with the increased activity of angiotensin II, which results in increased NADPH oxidase activity, reduced NO bioavailability and increased production of reactive oxygen species. Angiotensin II signaling activates matrix metalloproteinases (MMPs) which degrade TGFβ precursors to produce active TGFβ, which then results in increased arterial fibrosis. Angiotensin II signaling also activates cytokines, including monocyte chemoattractant protein-1, TNF-α, interleukin-1, interleukin-17 and interleukin-6. There is also ample clinical evidence that demonstrates the association of inflammation with increased arterial stiffness. Recent studies have shown that reductions in inflammation can reduce arterial stiffness. In patients with rheumatoid arthritis,increased aortic pulse wave velocity in patients was significantly reduced by anti tumor necrosis factor-α therapy. Among the major classes of anti hypertensive drugs, drugs that block the activation of the RAS system may be more effective in reducing the progression of arterial stiffness. Thus, there is rationale for targeting specific inflammatory pathways involved in arterial stiffness in the development of future drugs. Understanding the role of inflammation in the pathogenesis of arterial stiffness is important to understanding the complex puzzle that is the pathophysiology of arterial stiffening and may be important for future development of novel treatments.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Abramson JL / 2002 / Association between pulse pressure and C-reactive protein among apparently healthy US adults / Hypertension 39 : 197 ~ 202
Boutouyrie P / 2002 / Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study / Hypertension 39 : 10 ~ 15
Csiszar A / 2002 / Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar functio
Dart AM / 2001 / Pulse pressure--a review of mechanisms and clinical relevance / J Am Coll Cardiol 37 : 975 ~ 984
Domanski MJ / 1999 / Independent prognostic information provided by sphygmomanometrically determined pulse pressure and mean arterial pressure in patients with left ventricul
Boutouyrie P / 2002 / Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study / Hypertension 39 : 10 ~ 15
Csiszar A / 2002 / Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar functio
Dart AM / 2001 / Pulse pressure--a review of mechanisms and clinical relevance / J Am Coll Cardiol 37 : 975 ~ 984
Domanski MJ / 1999 / Independent prognostic information provided by sphygmomanometrically determined pulse pressure and mean arterial pressure in patients with left ventricul
이 논문의 저자 정보
최근 본 자료
댓글(0)
0