지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 352 - 357 (6page)
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Purpose: Anaplastic thyroid cancer is known to have a poor prognosis due to its aggressive and rapid metastasis with median survival of less than 6 months. Multimodal treatment involving surgery and chemoradiotherapy has been used to improve the survival of patients. Here, we retrospectively review of treatment outcome of 13 consecutive patients who were treated at a single center. Materials and Methods: We retrospectively reviewed medical records of 13 anaplastic thyroid cancer patients who received multidisciplinary treatment between 2006 and 2010. Kaplan-Meier survival curve was used to analyze progression-free survival and overall survival of patients. Results: The median patient age at diagnosis was 69 years, and six patients had stage IVc diseases. Eight patients received primary surgery followed by radiotherapy or concurrent chemoradiotherapy (CCRT). Five patients received weekly doxorubicin-based definitive CCRT, but only one patient’s condition remained stable, while the rest experienced rapid disease progression.
The median progression-free survival was 2.8 months (95% CI, 1.2-4.4 months), and the median overall survival was 3.8 months (95% CI, 3.0-4.6 months). Conclusion: Patients with anaplastic thyroid cancer showed poor prognosis despite multimodality treatment. Therefore, identification of novel therapeutic targets is warranted to take an effective mode of treatment.
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참고문헌 (22)
참고문헌 신청
Ain KB. / 2000 / Management of undifferentiated thyroid cancer / Baillieres Best Pract Res Clin Endocrinol Metab 14 : 615 ~ 629
Antonelli A / 2008 / Dedifferentiated thyroid cancer: a therapeutic challenge / Biomed Pharmacother 62 : 559 ~ 563
Antonelli A / 2008 / Primary cell cultures from anaplastic thyroid cancer obtained by fine-needle aspiration used for chemosensitivity tests / Clin Endocrinol (Oxf) 69 : 148
Baselga J / 2005 / Critical update and emerging trends in epidermal growth factor receptor targeting in cancer / J Clin Oncol 23 : 2445 ~ 2459
Chen J / 2008 / Surgery and radiotherapy improves survival in patients with anaplastic thyroid carcinoma: analysis of the surveillance, epidemiology, and end results 1983-200
Antonelli A / 2008 / Dedifferentiated thyroid cancer: a therapeutic challenge / Biomed Pharmacother 62 : 559 ~ 563
Antonelli A / 2008 / Primary cell cultures from anaplastic thyroid cancer obtained by fine-needle aspiration used for chemosensitivity tests / Clin Endocrinol (Oxf) 69 : 148
Baselga J / 2005 / Critical update and emerging trends in epidermal growth factor receptor targeting in cancer / J Clin Oncol 23 : 2445 ~ 2459
Chen J / 2008 / Surgery and radiotherapy improves survival in patients with anaplastic thyroid carcinoma: analysis of the surveillance, epidemiology, and end results 1983-200
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