지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 276 - 278 (3page)
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초록· 키워드
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Purpose: Subacute combined degeneration (SCD) involves progressive degeneration of the spinal cord, optic nerve, and peripheral nerves. Vitamin B12 (VB12) is a co-factor in myelin synthesis. Because each cell that constitutes the myelin component in the central nervous system and peripheral nervous system is different, it is improbable that these cells undergo simultaneous degeneration. However, the sequence of degeneration in SCD has not been established. Materials and Methods: In this study, we analysed medical records and electrophysiological data of patients who showed neurological symptoms and whose serum VB12 levels were lower than 200 pg/mL. Results: We enrolled 49 patients in this study. Their mean VB12 level was 68.3 pg/mL. Somatosensory evoked potential (SEP) study showed abnormal findings in 38 patients. Of the 40 patients who underwent visual evoked potential (VEP) study, 14 showed abnormal responses. Eighteen patients showed abnormal findings on a nerve conduction study (NCS). In this study, abnormal posterior tibial nerve SEPs only were seen in 16 patients, median nerve SEPs only were seen in 3 patients, abnormal VEPs only in two, and abnormal NCS responses in one patient. No patient complained of cognitive symptoms. Conclusion: In SCD, degeneration appears to progress in the following order: lower spinal cord, cervical spinal cord, peripheral nerve/optic nerve, and finally, the brain.
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참고문헌 (9)
참고문헌 신청
Aaron S / 2005 / Clinical and laboratory features and response to treatment in patients presenting with vitamin B12 deficiency-related neurological syndromes / Neurol India 5
Hemmer B / 1998 / Subacute combined degeneration: clinical, electrophysiological, and magnetic resonance imaging findings / J Neurol Neurosurg Psychiatry 65 : 822 ~ 827
Kwon KH / 1999 / Nerve conduction studies of sunacute combined degeneration / J Korean Neurol Assoc 17 : 259 ~ 265
Puri V / 2005 / Vitamin B12 deficiency: a clinical and electrophysiological profile / Electromyogr Clin Neurophysiol 45 : 273 ~ 284
Scalabrino G / 2009 / The multi-faceted basis of vitamin B12 (cobalamin) neurotrophism in adult central nervous system: lessons learned from its deficiency / Prog Neurobiol 8
Hemmer B / 1998 / Subacute combined degeneration: clinical, electrophysiological, and magnetic resonance imaging findings / J Neurol Neurosurg Psychiatry 65 : 822 ~ 827
Kwon KH / 1999 / Nerve conduction studies of sunacute combined degeneration / J Korean Neurol Assoc 17 : 259 ~ 265
Puri V / 2005 / Vitamin B12 deficiency: a clinical and electrophysiological profile / Electromyogr Clin Neurophysiol 45 : 273 ~ 284
Scalabrino G / 2009 / The multi-faceted basis of vitamin B12 (cobalamin) neurotrophism in adult central nervous system: lessons learned from its deficiency / Prog Neurobiol 8
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