지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 164 - 171 (8page)
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초록· 키워드
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Purpose: There is a concern on which antimicrobials are appropriate as empirical agents for community-onset acute pyelonephritis (APN) in regions where the fluoroquinolone resistance rate is high, such as in Korea. Materials and Methods: Three hundred and two strains of E. coli in 2001-2002 and 349 strains in 2008-2009 were isolated from the urine cultures of female adult APN patients, and the antimicrobial susceptibility was compared according to each study period. All the patients were classified as uncomplicated or complicated APN, and a subgroup analysis was done thereafter. Results: The E. coli strains isolated in 2008-2009 showed improved susceptibility to trimethoprim-sulfamethoxazole compared to those isolated in 2001-2002. However, the third generation cephalosporin and gentamicin susceptibility was worsened. Of the 232 isolates from the uncomplicated APN patients, there was no difference between the two different time periods. On the other hand, of the 419 isolates from the complicated APN patients, the susceptibility to third generation cephalosporin, gentamicin and ciprofloxacin was significantly worsened. Conclusion: The antimicrobial susceptibility of E. coli changed over the study period, however, this change occurred mainly in the complicated APN patients. In Korea, ciprofloxacin is still useful as an empirical agent for uncomplicated APN patients, but this is not the case for patients with complicated APN because of high resistance rate to ciprofloxacin in these patients. For the complicated APN patients, the rate of resistance to ciprofloxacin is already more than 30%.
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참고문헌 (24)
참고문헌 신청
American Thoracic Society / 2005 / Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia / Am J Respir C
Clinical and Laboratory Standards Institute / 2008 / Performance standards for antimicrobial susceptibility testing. 18th international supplement M100-S18. Document M7-A7 / Clinical an
Foxman B / 2003 / Acute pyelonephritis in US hospitals in 1997: hospitalization and in-hospital mortality / Ann Epidemiol 13 : 144 ~ 150
Goettsch W / 2000 / Increasing resistance to fluoroquinolones in escherichia coli from urinary tract infections in the Netherlands / J Antimicrob Chemother 46 : 223 ~ 228
Gupta K / 2001 / Increasing antimicrobial resistance and the management of uncomplicated community-acquired urinary tract infections / Ann Intern Med 135 : 41 ~ 50
Clinical and Laboratory Standards Institute / 2008 / Performance standards for antimicrobial susceptibility testing. 18th international supplement M100-S18. Document M7-A7 / Clinical an
Foxman B / 2003 / Acute pyelonephritis in US hospitals in 1997: hospitalization and in-hospital mortality / Ann Epidemiol 13 : 144 ~ 150
Goettsch W / 2000 / Increasing resistance to fluoroquinolones in escherichia coli from urinary tract infections in the Netherlands / J Antimicrob Chemother 46 : 223 ~ 228
Gupta K / 2001 / Increasing antimicrobial resistance and the management of uncomplicated community-acquired urinary tract infections / Ann Intern Med 135 : 41 ~ 50
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