지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 172 - 180 (9page)
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Purpose: Toxicity caused by acetaminophen and its toxic mechanisms in the liver have been widely studied, including effects involving metabolism and oxidative stress. However, its adverse effects on heart have not been sufficiently investigated. This study evaluated the cardiac influence and molecular events occurring within the myocardium in rats treated with a dose of acetaminophen large enough to induce conventional liver damage. Materials and Methods: Male rats were orally administered a single dose of acetaminophen at 1,000 mg/kg-body weight, and subsequently examined for conventional toxicological parameters and for gene expression alterations to both the heart and liver 24 hours after administration. Results: Following treatment, serum biochemical parameters including aspartate aminotransferase and alanine aminotransferase were elevated. Histopathological alterations of necrosis were observed in the liver, but not in the heart. However, alterations in gene expression were observed in both the liver and heart 24 hours after dosing. Transcriptional profiling revealed that acetaminophen changed the expression of genes implicated in oxidative stress, inflammatory processes, and apoptosis in the heart as well as in the liver. The numbers of up-regulated and down-regulated genes in the heart were 271 and 81, respectively, based on a two-fold criterion. Conclusion: The induced expression of genes implicated in oxidative stress and inflammatory processes in the myocardium reflects molecular levels of injury caused by acetaminophen (APAP), which could not be identified by conventional histopathology.
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참고문헌 (24)
참고문헌 신청
Albini A / 2010 / Cardiotoxicity of anticancer drugs: the need for cardio-oncology and cardio-oncological prevention / J Natl Cancer Inst 102 : 14 ~ 25
Benson V / 2007 / ICAM-1 in acute myocardial infarction: a potential therapeutic targ
Bronstein AC / 2007 / 2006 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS) / Clin Toxicol (Phila) 45 : 815 ~ 917
Chiu H / 2002 / Differential induction of heme oxygenase-1 in macrophages and hepatocytes during acetaminophen-induced hepatotoxicity in the rat: effects of hemin and bilive
Cook-Mills JM / 2002 / VCAM-1 signals during lymphocyte migration: role of reactive oxygen species / Mol Immunol 39 : 499 ~ 508
Benson V / 2007 / ICAM-1 in acute myocardial infarction: a potential therapeutic targ
Bronstein AC / 2007 / 2006 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS) / Clin Toxicol (Phila) 45 : 815 ~ 917
Chiu H / 2002 / Differential induction of heme oxygenase-1 in macrophages and hepatocytes during acetaminophen-induced hepatotoxicity in the rat: effects of hemin and bilive
Cook-Mills JM / 2002 / VCAM-1 signals during lymphocyte migration: role of reactive oxygen species / Mol Immunol 39 : 499 ~ 508
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