지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 15 - 34 (20page)
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Immunoglobulin G4-related systemic disease (IgG4-RSD) is a recently defined emerging entity characterized by a diffuse or mass forming inflammatory reaction rich in IgG4-positive plasma cells associated with fibrosclerosis and obliterative phlebitis. IgG4-RSD usually affects middle aged and elderly patients, with a male predominance. It is associated with an elevated serum titer of IgG4, which acts as a marker for this recently characterized entity. The prototype is IgG4-related sclerosing pancreatitis or autoimmune pancreatitis (AIP). Other common sites of involvement are the hepatobiliary tract, salivary gland, orbit, and lymph node, however practically any organ can be involved, including upper aerodigestive tract, lung, aorta, mediastinum,retroperitoneum, soft tissue, skin, central nervous system, breast, kidney, and prostate. Fever or constitutional symptoms usually do not comprise part of the clinical picture. Laboratory findings detected include raised serum globulin, IgG and IgG4. An association with autoantibody detection (such as antinuclear antibodies and rheumatoid factor) is seen in some cases. Steroid therapy comprises the mainstay of treatment. Disease progression with involvement of multiple organ-sites may be encountered in a subset of cases and may follow a relapsing-remitting course. The principal histopathologic findings in several extranodal sites include lymphoplasmacytic infiltration, lymphoid follicle formation, sclerosis and obliterative phlebitis, along with atrophy and destruction of tissues. Immunohistochemical staining shows increased IgG4+ cells in the involved tissues (>50 per high-power field, with IgG4/IgG ratio >40%). IgG4-RSD may potentially be rarely associated with the development of lymphoma and carcinoma. However, the nature and pathogenesis of IgG4-RSD are yet to be fully elucidated and provide immense scope for further studies.
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참고문헌 (26)
참고문헌 신청
Aalberse RC / 2009 / Immunoglobulin G4: an odd antibody / Clin Exp Allergy 39 : 469 ~ 477
Aparisi L / 2005 / Antibodies to carbonic anhydrase and IgG4 levels in idiopathic chronic pancreatitis: relevance for diagnosis of autoimmune pancreatitis / Gut 54 : 703 ~ 7
Aucouturier P / 1984 / Measurement of serum IgG4 levels by a competitive immunoenzymatic assay with monoclonal antibodies / J Immunol Methods 74 : 151 ~ 162
Brekke OH / 1994 / Human IgG isotype-specific amino acid residues affecting complement-mediated cell lysis and phagocytosis / Eur J Immunol 24 : 2542 ~ 2547
Deshpande V / 2005 / Autoimmune pancreatitis: more than just a pancreatic disease? A contemporary review of its pathology / Arch Pathol Lab Med 129 : 1148 ~ 1154
Aparisi L / 2005 / Antibodies to carbonic anhydrase and IgG4 levels in idiopathic chronic pancreatitis: relevance for diagnosis of autoimmune pancreatitis / Gut 54 : 703 ~ 7
Aucouturier P / 1984 / Measurement of serum IgG4 levels by a competitive immunoenzymatic assay with monoclonal antibodies / J Immunol Methods 74 : 151 ~ 162
Brekke OH / 1994 / Human IgG isotype-specific amino acid residues affecting complement-mediated cell lysis and phagocytosis / Eur J Immunol 24 : 2542 ~ 2547
Deshpande V / 2005 / Autoimmune pancreatitis: more than just a pancreatic disease? A contemporary review of its pathology / Arch Pathol Lab Med 129 : 1148 ~ 1154
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