지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 1,342 - 1,352 (11page)
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Purpose: This study tried to identify novel gastric autoimmune antigens that might be involved in aggravating the atrophic gastritis among patients with Helicobacter pylori infection using two-dimensional immunoblotting analysis. Materials and Methods: Proteins from gastric mucosal antrectomy specimens and AGS cells (gastric adenocarcinoma cell lines derived from a Caucasian patient who had received no prior therapy) were 2-dimensionally immunoblotted separately with a pool of 300 sera from H. pylroi-infected patients at Gyeongsang National University Hospital. Results: Thirty-eight autoantigenic proteins including alcohol dehydrogenase [NADP+], alpha enolase, gastrokine-1, gastric triacylglycerol lipase,heat shock 70 kDa protein 1, and peroxiredoxin-2 were identified in the gastric mucosal tissue. Fourteen autoantigenic proteins including programmed cell death 6-interacting protein, serum albumin and T-complex protein 1 subunit gamma were identified in the AGS cells. Albumin, alpha-enolase, annexin A3, cytoplasmic actin 1, heat shock cognate 71 kDa protein and leukocyte elastase inhibitor were commonly observed autoantigenic proteins in both gastric mucosal tissue and AGS cells. Alpha-enolase, glutathione S-transferase P, heat shock cognate 71 kDa protein, heat shock 70 kDa protein 1, human mitochondrial adenosine triphosphate synthase (ATP) subunit beta, mitochondrial 60 kDa heat shock protein, peroxiredoxin-2, 78 kDa glucose-regulated protein precursor, tyrosine-protein phosphatase non-receptor type 11 and Tryptophan-Aspartic acid (WD) repeat-containing protein 1 showed 60% or higher amino acid positivity. Conclusion: These newly identified gastric autoimmune antigens might be useful in the control and prevention of gastroduodenal disorders, and might be valuable in breaking the vicious circle that exists in gastroduodenal disorders if their pathophysiological roles could be understood in the progress of chronic atrophic gastritis, gastroduodenal ulcers, intestinal metaplasia, and gastric carcinogenesis.
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참고문헌 (25)
참고문헌 신청
Asahi A / 2008 / Helicobacter pylori eradication shifts monocyte Fcgamma receptor balance toward inhibit
Baik SC / 1990 / Prevalence of Helicobacter pylori infection among normal Korean adults / J Korean Soc Microbiol 25 : 455 ~ 462
Baik SC / 1996 / Increased oxidative DNA damage in Helicobacter pylori-infected human gastric mucosa / Cancer Res 56 : 1279 ~ 1282
Bassi V / 2010 / Identification of a correlation between Helicobacter pylori infection and Graves’ disease / Helicobacter 15 : 558 ~ 562
Birnie DH / 1998 / Association between antibodies to heat shock protein 65 and coronary atherosclerosis. Possible mechanism of action of Helicobacter pylori and other bacter
Baik SC / 1990 / Prevalence of Helicobacter pylori infection among normal Korean adults / J Korean Soc Microbiol 25 : 455 ~ 462
Baik SC / 1996 / Increased oxidative DNA damage in Helicobacter pylori-infected human gastric mucosa / Cancer Res 56 : 1279 ~ 1282
Bassi V / 2010 / Identification of a correlation between Helicobacter pylori infection and Graves’ disease / Helicobacter 15 : 558 ~ 562
Birnie DH / 1998 / Association between antibodies to heat shock protein 65 and coronary atherosclerosis. Possible mechanism of action of Helicobacter pylori and other bacter
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