지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 1,438 - 1,446 (9page)
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Purpose: Due to their comorbidities, dialysis patients have many chances to undergo radiologic procedures using iodinated contrast media. We aimed to assess time-sequenced blood oxidative stress level after contrast exposure in hemodialysis (HD) patients compared to those in the non-dialysis population. Materials and Methods:We included 21 anuric HD patients [HD-coronary angiography (CAG) group] and 23 persons with normal renal function (nonHD-CAG group) scheduled for CAG, and assessed 4 oxidative stress markers [advanced oxidation protein products (AOPP); catalase; 8-hydroxydeoxyguanosine; and malondialdehyde] before and after CAG, and subsequently up to 28 days. Results: In the nonHD-CAG group, only AOPP increased immediately after CAG and returned to baseline within one day. However, in the HD-CAG group, all four oxidative stress markers were significantly increased starting one day after CAG, and remained elevated longer than those in the nonHD-CAG group. Especially, AOPP level remained elevated for a month after contrast exposure. Conclusion: Our study showed that iodinated contrast media induces severe and prolonged oxidative stress in HD patients.
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참고문헌 (58)
참고문헌 신청
Heyman SN / 2010 / Reactive oxygen species and the pathogenesis of radiocontrast-induced nephropathy / Invest Radiol 45:188~195
Thiele H / 2010 / Impact of high-dose N-acetylcysteine versus placebo on contrast-induced nephropathy and myocardial reperfusion injury in unselected patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. The LIPSIA-N-ACC (Prospective, Single-Blind, Placebo-Controlled, Randomized Leipzig Immediate PercutaneouS Coronary Intervention Acute Myocardial Infarction N-ACC) Trial / J Am Coll Cardiol 55:2201~2209
Haeussler U / 2004 / Free reactive oxygen species and nephrotoxicity of contrast agents / Kidney Blood Press Res 27:167~171
Jo SH / 2009 / N-acetylcysteine versus AScorbic acid for preventing contrast-Induced nephropathy in patients with renal insufficiency undergoing coronary angiography NASPI study-a prospective randomized controlled trial / Am Heart J 157:576~583
Tasanarong A / 2009 / Protection of radiocontrast induced nephropathy by vitamin E (alpha tocopherol): a randomized controlled pilot study / J Med Assoc Thai 92:1273~1281
Thiele H / 2010 / Impact of high-dose N-acetylcysteine versus placebo on contrast-induced nephropathy and myocardial reperfusion injury in unselected patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. The LIPSIA-N-ACC (Prospective, Single-Blind, Placebo-Controlled, Randomized Leipzig Immediate PercutaneouS Coronary Intervention Acute Myocardial Infarction N-ACC) Trial / J Am Coll Cardiol 55:2201~2209
Haeussler U / 2004 / Free reactive oxygen species and nephrotoxicity of contrast agents / Kidney Blood Press Res 27:167~171
Jo SH / 2009 / N-acetylcysteine versus AScorbic acid for preventing contrast-Induced nephropathy in patients with renal insufficiency undergoing coronary angiography NASPI study-a prospective randomized controlled trial / Am Heart J 157:576~583
Tasanarong A / 2009 / Protection of radiocontrast induced nephropathy by vitamin E (alpha tocopherol): a randomized controlled pilot study / J Med Assoc Thai 92:1273~1281
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