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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 67 - 73 (7page)
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초록· 키워드
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Purpose: Methylphenidate (MPH) is one of the most commonly prescribed psychostimulants for attention deficit hyperactivity disorder (ADHD). However, there is limited research on its effects on lower urinary tract function. This study investigated changes in cystometric parameters after intragastric administration of MPH in conscious spontaneously hypertensive rats (SHRs), an animal model of ADHD.
Methods: Fourteen- to 16-week-old male SHRs (n=10), weighing between 280 and 315 g, were used. Three micturition cycles were recorded before administering MPH. One hour after each intragastric MPH injection, three cycles of cystometrogram were obtained in the awake condition. Various cystometric parameters were evaluated, including basal pressure (BP), maximal pressure (MP), threshold pressure (TP), bladder capacity (BC), micturition volume (MV), micturition interval (MI), and residual volume (RV). The data were analyzed using paired Student t -tests.
Results: Five SHRs were each administered a dose of 3-mg/kg MPH, and the other five received a dose of 6-mg/kg MPH. BP and MP increased significantly in the rats that received the 3-mg/kg MPH injection, but not in those that received the 6-mg/ kg injection. BC, MV, and MI significantly increased in the rats that received the 6-mg/kg MPH injection, but not in those that received the 3-mg/kg injection. There were no significant changes in TP after either injection.
Conclusions: Significant increases in BC, MV, and MI after the 6-mg/kg MPH injection suggest that the peripheral and the central nervous systems may play important roles in bladder function in those receiving MPH for ADHD.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Berry AK / 2009 / Methylphenidate for giggle incontinence / J Urol 182 (4 Suppl) : 2028 ~ 2032
Burgu B / 2011 / Lower urinary tract conditions in children with attention deficit hyperactivity disorder: correlation of symptoms based on validated scoring systems / J Urol
Carmack SA / 2014 / Animal model of methylphenidate’s long-term memory-enhancing effects / Learn Mem 21 : 82 ~ 89
Chang JH / 2011 / Clinical and urodynamic effect of methylphenidate for the treatment of giggle incontinence (enuresis risoria) / Neurourol Urodyn 30 : 1338 ~ 1342
Clouse AK / 2012 / Voltage-gated Na+ channel blockers reduce functional bladder capacity in the conscious spontaneously hypertensive rat / Urology 79 ( ) : 1410.e1 ~ 1410.e6
Burgu B / 2011 / Lower urinary tract conditions in children with attention deficit hyperactivity disorder: correlation of symptoms based on validated scoring systems / J Urol
Carmack SA / 2014 / Animal model of methylphenidate’s long-term memory-enhancing effects / Learn Mem 21 : 82 ~ 89
Chang JH / 2011 / Clinical and urodynamic effect of methylphenidate for the treatment of giggle incontinence (enuresis risoria) / Neurourol Urodyn 30 : 1338 ~ 1342
Clouse AK / 2012 / Voltage-gated Na+ channel blockers reduce functional bladder capacity in the conscious spontaneously hypertensive rat / Urology 79 ( ) : 1410.e1 ~ 1410.e6
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