지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 133 - 138 (6page)
이용수
초록· 키워드
오류제보하기
Puropose: It is known that anticholinergics induces cognitive dysfunction and may aggravate the
state of it. Tolterodine tartrate (detrusitolⓇ) is a widely known selective anticholinergics to bladder,
which does not cause a cognitive dysfunction. This study was designed to analyze the change of
cognitive function of brain disease patients, whom are taking anticholinesterase inhibitor with
tolterodine for overactive bladder (OAB).
Material and methods: From January 2001 to December 2004, with the patients whom have been
followed for the brain disease in the department of neurology, we have analyzed 79 patients with
tolterodine administered for OAB. We used K-MMSE (Korea minimental status examination) and
SNSB (seoul neuropsychological screening battery) to analyze the state of cognition. Mean age of
patients was 67.3±4.5 (yrs), mean administration period was 4.7±9.5 (mon).
Results: 7 patients made complaints for the decline of memory, 2 of them with Parkinsonism
and 2 with cerebral infarction, 1 with progressive supranuclear palsy and, 2 dementia with lewy
body (DLB). Patients with DLB was excluded in this study because the disease had fluctuation of
cognitive function.
Conclusions: The result of these studies demonstrates tolterodine tartrate caused the decline of
cognitive function in only a few patients with brain disease. We concluded that prospective studies
are needed to change the cognitive functions of the brain disease patients with OAB after administration
of tolterodine tartrate. (J Korean Continence Soc 2008;12:133-8)
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Abrams P / 2003 / The standardization of terminology of lower urinary tract function: Report from the Standardization Sub-committee of the International Continence Society /
Agnoli A / 1983 / Effect of cholinergic and anticholinergic drugs on short-term memory in Alzheimer’s dementia: a neuropsychological and computerized electroencephalographic
Appell RA / 2001 / Prospective randomized controlled trial of extended-release oxybutynin chloride and tolterodine tartrate in the treatment of overactive bladder: Results o
Bedard MA / 1999 / Acute and long-term administration of anticholinergics in Parkinson’s disease: specific effects on the subcortico-frontal syndrome / Brain Cogn 40 : 289 ~
Blazer DG II / 1983 / Schaffner W. The risk of anticholinergic toxicity in the elderly: A study of prescribing practices in two populations / J Gerontol 38 : 31 ~ 35
Agnoli A / 1983 / Effect of cholinergic and anticholinergic drugs on short-term memory in Alzheimer’s dementia: a neuropsychological and computerized electroencephalographic
Appell RA / 2001 / Prospective randomized controlled trial of extended-release oxybutynin chloride and tolterodine tartrate in the treatment of overactive bladder: Results o
Bedard MA / 1999 / Acute and long-term administration of anticholinergics in Parkinson’s disease: specific effects on the subcortico-frontal syndrome / Brain Cogn 40 : 289 ~
Blazer DG II / 1983 / Schaffner W. The risk of anticholinergic toxicity in the elderly: A study of prescribing practices in two populations / J Gerontol 38 : 31 ~ 35
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