지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 1,158 - 1,167 (10page)
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Purpose: NAD(P)H:Quinone Oxidoreductase 1 (NQO1) C609T missense variant (NQO1*2) and 29 basepair (bp)-insertion/deletion (I29/D) polymorphism of the NRH:Quinone Oxidoreductase 2 (NQO2) gene promoter have been proposed as predictive and prognostic factors for cancer development and progression. The purpose of this study is to investigate the relationship between NQO1/NQO2 genotype and clinico-pathological features of papillary thyroid microcarcinoma (PTMC). Materials and Methods: Genomic DNA was isolated from 243 patients;and clinical data were retrospectively analyzed. NQO1*2 and tri-allelic polymorphism of NQO2 were investigated by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. Results: PTMC with NQO1*2 frequently exhibited extra-thyroidal extension as compared to PTMC with wild-type NQO1 (p=0.039). There was a significant relationship between I29/I29 homozygosity of NQO2 and lymph node metastasis (p=0.042). Multivariate analysis showed that the I29/I29 genotype was associated with an increased risk of lymph node metastasis (OR, 2.24; 95% CI, 1.10-4.56; p=0.026). Conclusion: NQO1*2 and I29 allele of the NQO2 are associated with aggressive clinical phenotypes of PTMC, and the I29 allele represents a putative prognostic marker for PTMC.
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참고문헌 (22)
참고문헌 신청
Chen AY / 2009 / Increasing incidence of differentiated thyroid cancer in the United States, 1988-2005 / Cancer 115 : 3801 ~ 3807
Chen W / 2011 / Effects of long-term exposure to iodine excess on the apoptosis of thyrocytes in Wistar rats / Exp Clin Endocrinol Diabetes 119 : 1 ~ 8
Fagerholm R / 2008 / NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer / Nat Genet 40 : 844 ~ 853
Farid NR / 2001 / P53 mutations in thyroid carcinoma: tidings from an old foe / J Endocrinol Invest 24 : 536 ~ 545
Gossen JA / 1993 / Plasmid rescue from transgenic mouse DNA using LacI repressor protein conjugated to magnetic beads / Biotechniques 14 : 624 ~ 629
Chen W / 2011 / Effects of long-term exposure to iodine excess on the apoptosis of thyrocytes in Wistar rats / Exp Clin Endocrinol Diabetes 119 : 1 ~ 8
Fagerholm R / 2008 / NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer / Nat Genet 40 : 844 ~ 853
Farid NR / 2001 / P53 mutations in thyroid carcinoma: tidings from an old foe / J Endocrinol Invest 24 : 536 ~ 545
Gossen JA / 1993 / Plasmid rescue from transgenic mouse DNA using LacI repressor protein conjugated to magnetic beads / Biotechniques 14 : 624 ~ 629
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