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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 603 - 608 (6page)
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Purpose: Mitofusin2 gene (Mfn2, also named Hyperplasia suppressive gene, HSG) is very important in the origin and development of hypertension. However, the mechanism of Mfn2/HSG expression regulation was not uncovered. This study was designed to explore the association of a novel 5’-uncoding region (UCR) -1248 A>G variation of HSG/Mfn2 gene and hypertension. Materials and Methods: 472 healthy, normotensive subjects [normotension (NT) group], 454 prehypertensive subjects [prehypertension (PH) group] and 978 hypertensive patients [essential hypertension (EH) group] were screened for an association study between 5’-UCR -1248 A>G of Mfn2/HSG and hypertension by polymerase chain reaction and DNA sequencing after venous blood was drawn and DNA was extracted. Results: When comparing the A and G frequency in EH, PH and NT groups, in total, NT group significantly had higher A frequency than in PH group [odds ratio (OR)=1.605, confidence interval (CI) 95%=1.063-2.242, p=0.025] and EH group (OR=5.395, CI 95%=3.783-7.695, p<0.01). When subgrouped by gender, A frequency in NT group was still significantly higher than in EH group (male: OR= 4.264, CI 95%=2.780-6.543, p<0.01; female: OR=8.897, CI 95%=4.686-16.891, p<0.01), but not from PH group, either in male group or in female group. Ordinal Logistic Regression analysis showed that A>G variation was significantly related with blood pressure level (B=-1.271, Wald=40.914, CI 95%=-1.660 - -0.881, p<0.01). Conclusion: 5’-UCR -1248 A>G variation of Mfn2/HSG gene was a novel variation and may be associated with hypertension in Chinese.
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참고문헌 (20)
참고문헌 신청
Chen KH / 2004 / Dysregulation of HSG triggers vascular proliferative disorders / Nat Cell Biol 6 : 872 ~ 883
Farre D / 2003 / Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN / Nucleic Acids Res 31 : 3651 ~ 3653
Guo X / 2007 / Mitofusin 2 triggers vascular smooth muscle cell apoptosis via mitochondrial death pathway / Circ Res 101 : 1113 ~ 1122
Huang P / 2011 / Control of mitochondrial morphology through differential interactions of mitochondrial fusion and fission proteins / PLoS One 6 : e20655 ~
Katkoori VR / 2008 / Clinical significance of a novel single nucleotide polymorphism in the 5’ untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcino
Farre D / 2003 / Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN / Nucleic Acids Res 31 : 3651 ~ 3653
Guo X / 2007 / Mitofusin 2 triggers vascular smooth muscle cell apoptosis via mitochondrial death pathway / Circ Res 101 : 1113 ~ 1122
Huang P / 2011 / Control of mitochondrial morphology through differential interactions of mitochondrial fusion and fission proteins / PLoS One 6 : e20655 ~
Katkoori VR / 2008 / Clinical significance of a novel single nucleotide polymorphism in the 5’ untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcino
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